TY - JOUR
T1 - NeuroImmunoEndocrinology
T2 - A brief historic narrative
AU - Ponce-Regalado, María Dolores
AU - Pérez-Sánchez, Gilberto
AU - Rojas-Espinosa, Oscar
AU - Arce-Paredes, Patricia
AU - Girón-Peréz, M. Iván
AU - Pavón-Romero, Lenin
AU - Becerril-Villanueva, Enrique
N1 - Publisher Copyright:
©2022 Society for Leukocyte Biology.
PY - 2022/7
Y1 - 2022/7
N2 - Although no precise moment or unique event marks its birth, neuroimmunoendocrinology arguably shares a great deal of history with other medical and biologic disciplines. It originated from empirical observations and suppositions that failed to prevail upon the existing axioms. Despite the widespread resistance to embracing novel ideas, the seeming defeats inspired visionary researchers. Those pioneers managed to systematize the emerging knowledge and were able to contribute to science with real foundations. In consequence, new concepts and ideas arose in physiology, anatomy, endocrinology and early immunology. Together, they gave rise to a budding approach on the integration between the nervous, immune and endocrine systems. Then, neuroimmunoendocrinology emerged as a discipline integrating an intricate system with multidirectional functions and interactions that allow for responding to internal and external threats. Such response is mediated by cytokines, hormones and neurotransmitters, involved in different physiologic mechanisms of the organism homeostasis. Neuroimmunoendocrinology is no longer an area of scientific skepticism; on the contrary, it has cemented its position as a biomedical discipline worldwide for the past 70 years. Now, it offers a better understanding of pathologic processes.
AB - Although no precise moment or unique event marks its birth, neuroimmunoendocrinology arguably shares a great deal of history with other medical and biologic disciplines. It originated from empirical observations and suppositions that failed to prevail upon the existing axioms. Despite the widespread resistance to embracing novel ideas, the seeming defeats inspired visionary researchers. Those pioneers managed to systematize the emerging knowledge and were able to contribute to science with real foundations. In consequence, new concepts and ideas arose in physiology, anatomy, endocrinology and early immunology. Together, they gave rise to a budding approach on the integration between the nervous, immune and endocrine systems. Then, neuroimmunoendocrinology emerged as a discipline integrating an intricate system with multidirectional functions and interactions that allow for responding to internal and external threats. Such response is mediated by cytokines, hormones and neurotransmitters, involved in different physiologic mechanisms of the organism homeostasis. Neuroimmunoendocrinology is no longer an area of scientific skepticism; on the contrary, it has cemented its position as a biomedical discipline worldwide for the past 70 years. Now, it offers a better understanding of pathologic processes.
KW - neuroimmunoendocrinology
KW - neuroimmunomodulation
KW - neurophysiology and immunoregulation
KW - nueroendocrinology
KW - psychoimmunology
KW - psychoneuroimmunology
UR - http://www.scopus.com/inward/record.url?scp=85123923582&partnerID=8YFLogxK
U2 - 10.1002/JLB.5MR1221-287R
DO - 10.1002/JLB.5MR1221-287R
M3 - Artículo de revisión
C2 - 35098580
AN - SCOPUS:85123923582
SN - 0741-5400
VL - 112
SP - 97
EP - 114
JO - Journal of Leukocyte Biology
JF - Journal of Leukocyte Biology
IS - 1
ER -