TY - JOUR
T1 - Neonatal ventral hippocampus lesion disrupts maternal behavior in rats
T2 - An animal model of schizophrenia
AU - Sánchez-Olguin, Claudia P.
AU - Zamudio, Sergio R.
AU - Guzmán-Velázquez, Sonia
AU - Márquez-Portillo, Mariana
AU - Caba-Flores, Mario Daniel
AU - Camacho-Abrego, Israel
AU - Flores, Gonzalo
AU - Melo, Angel I.
N1 - Publisher Copyright:
© 2022 Wiley Periodicals LLC.
PY - 2022/9
Y1 - 2022/9
N2 - Although individuals with schizophrenia typically present deficits in social interaction, little is known about the quality of their parent–infant interactions. In the present study, we assessed the behavioral effects of neonatal ventral hippocampus lesion (nVHL) in female rats (nVHL is known to induce schizophrenia-like deficits in males). Sexually naïve adult nVHL or sham female rats received cognitive and social tests, and their maternal behavior was observed in independent groups of adult nVHL and sham rats on postpartum days 2, 6, and 12. Compared to Sham females, naïve nVHL rats displayed elevated locomotor activity, less social interaction, and disrupted habituation of the acoustic startle response (ASR), while dorsal immobility (a defensive behavioral response) and prepulse inhibition of ASR were not affected. Although all nVHL mothers retrieved their pups, adopted the crouching posture, and nursed them, they showed disturbances in the display of pup body licking and nest building. Furthermore, a high proportion of nVHL mothers displayed atypical retrieval of pups and re-retrieving of pups, atypical nest-building, excavation, and cannibalism, as well a high level of these behaviors. These data indicate that cognition, locomotor activity, and maternal care is disrupted in nVHL female, suggesting disturbances in mesocorticolimbic dopaminergic systems and/or in social cognition.
AB - Although individuals with schizophrenia typically present deficits in social interaction, little is known about the quality of their parent–infant interactions. In the present study, we assessed the behavioral effects of neonatal ventral hippocampus lesion (nVHL) in female rats (nVHL is known to induce schizophrenia-like deficits in males). Sexually naïve adult nVHL or sham female rats received cognitive and social tests, and their maternal behavior was observed in independent groups of adult nVHL and sham rats on postpartum days 2, 6, and 12. Compared to Sham females, naïve nVHL rats displayed elevated locomotor activity, less social interaction, and disrupted habituation of the acoustic startle response (ASR), while dorsal immobility (a defensive behavioral response) and prepulse inhibition of ASR were not affected. Although all nVHL mothers retrieved their pups, adopted the crouching posture, and nursed them, they showed disturbances in the display of pup body licking and nest building. Furthermore, a high proportion of nVHL mothers displayed atypical retrieval of pups and re-retrieving of pups, atypical nest-building, excavation, and cannibalism, as well a high level of these behaviors. These data indicate that cognition, locomotor activity, and maternal care is disrupted in nVHL female, suggesting disturbances in mesocorticolimbic dopaminergic systems and/or in social cognition.
KW - habituation of ASR
KW - maternal behavior
KW - neonatal ventral hippocampus lesion
KW - schizophrenia
KW - sensorimotor gating
KW - social cognition
KW - social interaction
UR - http://www.scopus.com/inward/record.url?scp=85132557403&partnerID=8YFLogxK
U2 - 10.1002/dev.22283
DO - 10.1002/dev.22283
M3 - Artículo
C2 - 35748629
AN - SCOPUS:85132557403
SN - 0012-1630
VL - 64
JO - Developmental Psychobiology
JF - Developmental Psychobiology
IS - 6
M1 - e22283
ER -