TY - JOUR
T1 - Natural marine products as antiprotozoal agents against amitochondrial parasites
AU - Estrella-Parra, Edgar Antonio
AU - Arreola, Rodrigo
AU - Álvarez-Sánchez, Maria Elizbeth
AU - Torres-Romero, Julio César
AU - Rojas-Espinosa, Oscar
AU - De la Cruz-Santiago, José Alberto
AU - Martinez-Benitez, Máximo Berto
AU - López-Camarillo, Cesar
AU - Lara-Riegos, Julio Cesar
AU - Arana-Argáez, Víctor E.
AU - Ramírez-Camacho, Mario A.
N1 - Publisher Copyright:
© 2022 The Authors
PY - 2022/8
Y1 - 2022/8
N2 - The goal of this work is to compile and discuss molecules of marine origin reported in the scientific literature with anti-parasitic activity against Trichomonas, Giardia, and Entamoeba, parasites responsible for diseases that are major global health problems, and Microsporidial parasites as an emerging problem. The presented data correspond to metabolites with anti-parasitic activity in human beings that have been isolated by chromatographic techniques from marine sources and structurally elucidated by spectroscopic and spectrometric procedures. We also highlight some semi-synthetic derivatives that have been successful in enhancing the activity of original compounds. The biological oceanic reservoir offers the possibility to discover new biologically active molecules as lead compounds to develop new drug candidates. The molecular variety is extensive and must be correctly explored and managed. Also, it will be necessary to take some actions to preserve the source species from extinction or overharvest (e.g., by cryopreservation of coral spermatozoa, oocytes, embryos, and larvae) and coordinate appropriate exploitation to increase the chemical knowledge of the natural products generated in the oceans. Additional initiatives such as the total synthesis of complex natural products and their derivatives can help to prevent overharvest of the marine ecosystems and at the same time contribute to the discovery of new molecules.
AB - The goal of this work is to compile and discuss molecules of marine origin reported in the scientific literature with anti-parasitic activity against Trichomonas, Giardia, and Entamoeba, parasites responsible for diseases that are major global health problems, and Microsporidial parasites as an emerging problem. The presented data correspond to metabolites with anti-parasitic activity in human beings that have been isolated by chromatographic techniques from marine sources and structurally elucidated by spectroscopic and spectrometric procedures. We also highlight some semi-synthetic derivatives that have been successful in enhancing the activity of original compounds. The biological oceanic reservoir offers the possibility to discover new biologically active molecules as lead compounds to develop new drug candidates. The molecular variety is extensive and must be correctly explored and managed. Also, it will be necessary to take some actions to preserve the source species from extinction or overharvest (e.g., by cryopreservation of coral spermatozoa, oocytes, embryos, and larvae) and coordinate appropriate exploitation to increase the chemical knowledge of the natural products generated in the oceans. Additional initiatives such as the total synthesis of complex natural products and their derivatives can help to prevent overharvest of the marine ecosystems and at the same time contribute to the discovery of new molecules.
KW - Antiprotozoal
KW - Entamoeba
KW - Giardia
KW - Microsporidia
KW - Parasites
KW - Trichomonas
UR - http://www.scopus.com/inward/record.url?scp=85130811025&partnerID=8YFLogxK
U2 - 10.1016/j.ijpddr.2022.05.003
DO - 10.1016/j.ijpddr.2022.05.003
M3 - Artículo de revisión
C2 - 35636129
AN - SCOPUS:85130811025
SN - 2211-3207
VL - 19
SP - 40
EP - 46
JO - International Journal for Parasitology: Drugs and Drug Resistance
JF - International Journal for Parasitology: Drugs and Drug Resistance
ER -