TY - JOUR
T1 - Moringa oleifera, a species with potential analgesic and anti-inflammatory activities
AU - Martínez-González, Claudia Lizbeth
AU - Martínez, Laura
AU - Martínez-Ortiz, Efraín J.
AU - González-Trujano, María Eva
AU - Déciga-Campos, Myrna
AU - Ventura-Martínez, Rosa
AU - Díaz-Reval, Irene
N1 - Publisher Copyright:
© 2016 Elsevier Masson SAS
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Moringa oleifera has long been used in large demand in folk medicine to treat pain. The present study was undertaken to examine the antinociceptive and anti-inflammatory spectrum of M. oleifera leaf extracts discriminating the constituents’ nature by using different kind of experimental models in rats. Pharmacological evaluation of a non-polar and/or polar extracts at several doses (30–300 mg/kg, p.o.) was explored through experimental nociception using formalin test, carrageenan-induced paw edema and arthritis with subcutaneous injection of collagen in rats. Basic morphology characterization was done by scanning electronic microscopy and laser scanning confocal microscopy. Not only polar (from 30 or 100 mg/kg, p.o.) but also non-polar extract produced significant inhibition of the nociceptive behavior with major efficacy in the inflammatory response in different assessed experimental models. This antinociceptive activity involved constituents of different nature and depended on the intensity of the induced painful stimulus. Phytochemical analysis showed the presence of kaempferol-3-glucoside in the polar extract and fatty acids like chlorogenic acid, among others, in the non-polar extract. Data obtained with M. oleifera leaf extracts give evidence of its potential for pain treatment.
AB - Moringa oleifera has long been used in large demand in folk medicine to treat pain. The present study was undertaken to examine the antinociceptive and anti-inflammatory spectrum of M. oleifera leaf extracts discriminating the constituents’ nature by using different kind of experimental models in rats. Pharmacological evaluation of a non-polar and/or polar extracts at several doses (30–300 mg/kg, p.o.) was explored through experimental nociception using formalin test, carrageenan-induced paw edema and arthritis with subcutaneous injection of collagen in rats. Basic morphology characterization was done by scanning electronic microscopy and laser scanning confocal microscopy. Not only polar (from 30 or 100 mg/kg, p.o.) but also non-polar extract produced significant inhibition of the nociceptive behavior with major efficacy in the inflammatory response in different assessed experimental models. This antinociceptive activity involved constituents of different nature and depended on the intensity of the induced painful stimulus. Phytochemical analysis showed the presence of kaempferol-3-glucoside in the polar extract and fatty acids like chlorogenic acid, among others, in the non-polar extract. Data obtained with M. oleifera leaf extracts give evidence of its potential for pain treatment.
KW - Antinociception
KW - Chlorogenic acid
KW - Folk medicine
KW - Kaempferol-3-glucoside
KW - Moringa oleifera
KW - Morphology
KW - Scanning electronic microscopy
UR - http://www.scopus.com/inward/record.url?scp=85008658870&partnerID=8YFLogxK
U2 - 10.1016/j.biopha.2016.12.107
DO - 10.1016/j.biopha.2016.12.107
M3 - Artículo
C2 - 28073097
SN - 0753-3322
VL - 87
SP - 482
EP - 488
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
ER -