TY - JOUR
T1 - More evidence for the genetic susceptibility of Mexican population to nonalcoholic fatty liver disease through PNPLA3
AU - Chinchilla-López, Paulina
AU - Ramírez-Pérez, Oscar
AU - Cruz-Ramón, Vania
AU - Canizales-Quinteros, Samuel
AU - Domínguez-López, Aarón
AU - Ponciano-Rodríguez, Guadalupe
AU - Sánchez-Muñoz, Fausto
AU - Méndez-Sánchez, Nahum
N1 - Publisher Copyright:
© 2018, Fundacion Clinica Medica Sur. All rights reserved.
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Background. The gene for patatin-like phospholipase domain containing 3 (PNPLA3) is associated with non-alcoholic fatty liver disease (NAFLD) development. We previously found that Mexican indigenous population had the highest frequency reported of the PNPLA3 148M risk allele. Further, we observed a relationship between M148M genotype with elevated ALT levels in individuals with normal weight, overweight and obese. We sought to investigate whether PNPLA3 polymorphism is associated with NAFLD development in Mexicans. Material and methods. We enrolled 189 Mexican patients with NAFLD and 201 healthy controls. Anthropometric, metabolic, and biochemical variables were measured, and rs738409 (Ile148Met substitution) polymorphism was genotyped by sequencing. Results. Logistic regression analysis, using a recessive model, suggested that PNPLA3 polymorphism in Mexican population is significantly associated (OR = 1.711, 95% CI: 1.014-2.886; P = 0.044) with NAFLD. Conclusions: The PNPLA3 gene is associated with NAFLD in Mexican population. More studies are required to explain the high prevalence of PNPLA3 polymorphism in Mexican-Americans, Mexican-Indians, and Mexican-Mestizos.
AB - Background. The gene for patatin-like phospholipase domain containing 3 (PNPLA3) is associated with non-alcoholic fatty liver disease (NAFLD) development. We previously found that Mexican indigenous population had the highest frequency reported of the PNPLA3 148M risk allele. Further, we observed a relationship between M148M genotype with elevated ALT levels in individuals with normal weight, overweight and obese. We sought to investigate whether PNPLA3 polymorphism is associated with NAFLD development in Mexicans. Material and methods. We enrolled 189 Mexican patients with NAFLD and 201 healthy controls. Anthropometric, metabolic, and biochemical variables were measured, and rs738409 (Ile148Met substitution) polymorphism was genotyped by sequencing. Results. Logistic regression analysis, using a recessive model, suggested that PNPLA3 polymorphism in Mexican population is significantly associated (OR = 1.711, 95% CI: 1.014-2.886; P = 0.044) with NAFLD. Conclusions: The PNPLA3 gene is associated with NAFLD in Mexican population. More studies are required to explain the high prevalence of PNPLA3 polymorphism in Mexican-Americans, Mexican-Indians, and Mexican-Mestizos.
KW - Epigenetics
KW - Non-alcoholic fatty liver disease
KW - Patatin domain
KW - Rs738409
UR - http://www.scopus.com/inward/record.url?scp=85042253529&partnerID=8YFLogxK
U2 - 10.5604/01.3001.0010.8644
DO - 10.5604/01.3001.0010.8644
M3 - Artículo
C2 - 29469042
SN - 1665-2681
VL - 17
SP - 250
EP - 255
JO - Annals of Hepatology
JF - Annals of Hepatology
IS - 2
ER -