Mollicutes antibiotic resistance profile and presence of genital abnormalities in couples attending an infertility clinic

Brenda Maldonado-Arriaga, Noé Escobar-Escamilla, Juan Carlos Pérez-Razo, Sofia Lizeth Alcaráz-Estrada, Ignacio Flores-Sánchez, Daniel Moreno-García, Rebeca Pérez-Cabeza de Vaca, Paul Mondragón-Terán, Jonathan Shaw, Cecilia Hernandez-Cortez, Graciela Castro-Escarpulli, Juan Antonio Suárez-Cuenca

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    Abstract

    Objective: The present study aimed to identify Mollicutes infection in the reproductive system. We also examined the microbiological, biochemical, and antimicrobial profiles of Mollicutes infection, which are potentially associated with clinical reproductive abnormalities causing infertility in couples. Methods: Thirty-seven couples who were attending an infertility clinic were enrolled. Detection of genital mycoplasmas was performed in cervicovaginal samples or male urethral swabs. Microbiological culture and biochemical and antimicrobial profiles were characterized using a Mycoplasma kit. The results were associated with reproductive abnormalities, as assessed by medical specialists from the infertility clinic. Results: Up to 28.3% of all biological samples (n = 74) showed positive cultures. Bacterial isolates were Ureaplasma urealyticum (71.4%), Mycoplasma hominis (9.5%), or coinfections (19%). Most Mollicutes showed significant resistance to fluoroquinolones, macrolides, and tetracycline; and showed susceptibility to doxycycline, josamycin, and pristinamycin. The presence of resistant strains to any antibiotic was significantly associated with genital abnormalities (χ2 test, relative risk = 11.38 [95% confidence interval: 5.8–22.9]), particularly in women. The highest statistical association was found for macrolide-resistant strains. Conclusion: The microbiological antibiotic resistance profile is epidemiologically associated with abnormalities of the reproductive system in couples attending an infertility clinic.

    Original languageEnglish
    JournalJournal of International Medical Research
    Volume48
    Issue number1
    DOIs
    StatePublished - 1 Jan 2019

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    Keywords

    • antimicrobial resistance profile
    • bacterial isolate
    • infertility
    • Mollicutes
    • Mycoplasma
    • reproductive abnormalities

    Cite this

    Maldonado-Arriaga, B., Escobar-Escamilla, N., Pérez-Razo, J. C., Alcaráz-Estrada, S. L., Flores-Sánchez, I., Moreno-García, D., Pérez-Cabeza de Vaca, R., Mondragón-Terán, P., Shaw, J., Hernandez-Cortez, C., Castro-Escarpulli, G., & Suárez-Cuenca, J. A. (2019). Mollicutes antibiotic resistance profile and presence of genital abnormalities in couples attending an infertility clinic. Journal of International Medical Research, 48(1). https://doi.org/10.1177/0300060519828945