TY - JOUR
T1 - Mollicutes antibiotic resistance profile and presence of genital abnormalities in couples attending an infertility clinic
AU - Maldonado-Arriaga, Brenda
AU - Escobar-Escamilla, Noé
AU - Pérez-Razo, Juan Carlos
AU - Alcaráz-Estrada, Sofia Lizeth
AU - Flores-Sánchez, Ignacio
AU - Moreno-García, Daniel
AU - Pérez-Cabeza de Vaca, Rebeca
AU - Mondragón-Terán, Paul
AU - Shaw, Jonathan
AU - Hernandez-Cortez, Cecilia
AU - Castro-Escarpulli, Graciela
AU - Suárez-Cuenca, Juan Antonio
N1 - Publisher Copyright:
© The Author(s) 2019.
PY - 2019/1
Y1 - 2019/1
N2 - Objective: The present study aimed to identify Mollicutes infection in the reproductive system. We also examined the microbiological, biochemical, and antimicrobial profiles of Mollicutes infection, which are potentially associated with clinical reproductive abnormalities causing infertility in couples. Methods: Thirty-seven couples who were attending an infertility clinic were enrolled. Detection of genital mycoplasmas was performed in cervicovaginal samples or male urethral swabs. Microbiological culture and biochemical and antimicrobial profiles were characterized using a Mycoplasma kit. The results were associated with reproductive abnormalities, as assessed by medical specialists from the infertility clinic. Results: Up to 28.3% of all biological samples (n = 74) showed positive cultures. Bacterial isolates were Ureaplasma urealyticum (71.4%), Mycoplasma hominis (9.5%), or coinfections (19%). Most Mollicutes showed significant resistance to fluoroquinolones, macrolides, and tetracycline; and showed susceptibility to doxycycline, josamycin, and pristinamycin. The presence of resistant strains to any antibiotic was significantly associated with genital abnormalities (χ2 test, relative risk = 11.38 [95% confidence interval: 5.8–22.9]), particularly in women. The highest statistical association was found for macrolide-resistant strains. Conclusion: The microbiological antibiotic resistance profile is epidemiologically associated with abnormalities of the reproductive system in couples attending an infertility clinic.
AB - Objective: The present study aimed to identify Mollicutes infection in the reproductive system. We also examined the microbiological, biochemical, and antimicrobial profiles of Mollicutes infection, which are potentially associated with clinical reproductive abnormalities causing infertility in couples. Methods: Thirty-seven couples who were attending an infertility clinic were enrolled. Detection of genital mycoplasmas was performed in cervicovaginal samples or male urethral swabs. Microbiological culture and biochemical and antimicrobial profiles were characterized using a Mycoplasma kit. The results were associated with reproductive abnormalities, as assessed by medical specialists from the infertility clinic. Results: Up to 28.3% of all biological samples (n = 74) showed positive cultures. Bacterial isolates were Ureaplasma urealyticum (71.4%), Mycoplasma hominis (9.5%), or coinfections (19%). Most Mollicutes showed significant resistance to fluoroquinolones, macrolides, and tetracycline; and showed susceptibility to doxycycline, josamycin, and pristinamycin. The presence of resistant strains to any antibiotic was significantly associated with genital abnormalities (χ2 test, relative risk = 11.38 [95% confidence interval: 5.8–22.9]), particularly in women. The highest statistical association was found for macrolide-resistant strains. Conclusion: The microbiological antibiotic resistance profile is epidemiologically associated with abnormalities of the reproductive system in couples attending an infertility clinic.
KW - Mollicutes
KW - Mycoplasma
KW - antimicrobial resistance profile
KW - bacterial isolate
KW - infertility
KW - reproductive abnormalities
UR - http://www.scopus.com/inward/record.url?scp=85078687957&partnerID=8YFLogxK
U2 - 10.1177/0300060519828945
DO - 10.1177/0300060519828945
M3 - Artículo
C2 - 30819052
AN - SCOPUS:85078687957
SN - 0300-0605
VL - 48
JO - Journal of International Medical Research
JF - Journal of International Medical Research
IS - 1
ER -