Molecular markers in the epidemiology and diagnosis of coccidioidomycosis

Esperanza Duarte-Escalante, María Guadalupe Frías-De-León, Gerardo Zúñiga, Erick Martínez-Herrera, Gustavo Acosta-Altamirano, María del Rocío Reyes-Montes

Research output: Contribution to journalShort survey

3 Citations (Scopus)

Abstract

The prevalence of coccidioidomycosis in endemic areas has been observed to increase daily. To understand the causes of the spread of the disease and design strategies for fungal detection in clinical and environmental samples, scientists have resorted to molecular tools that allow fungal detection in a natural environment, reliable identification in clinical cases and the study of biological characteristics, such as reproductive and genetic structure, demographic history and diversification. We conducted a review of the most important molecular markers in the epidemiology of Coccidioides spp. and the diagnosis of coccidioidomycosis. A literature search was performed for scientific publications concerning the application of molecular tools for the epidemiology and diagnosis of coccidioidomycosis. The use of molecular markers in the epidemiological study and diagnosis of coccidioidomycosis has allowed for the typing of Coccidioides spp. isolates, improved understanding of their mode of reproduction, genetic variation and speciation and resulted in the development specific, rapid and sensitive strategies for detecting the fungus in environmental and clinical samples. Molecular markers have revealed genetic variability in Coccidioides spp. This finding influences changes in the epidemiology of coccidioidomycosis, such as the emergence of more virulent or antifungal resistant genotypes. Furthermore, the molecular markers currently used to identify Coccidioides immitis and Coccidioides posadasii are specific and sensitive. However, they must be validated to determine their application in diagnosis.This manuscript is part of the series of works presented at the "V International Workshop: Molecular genetic approaches to the study of human pathogenic fungi" (Oaxaca, Mexico, 2012). © 2013 Revista Iberoamericana de Micología.
Original languageAmerican English
Pages (from-to)49-53
Number of pages43
JournalRevista Iberoamericana de Micologia
DOIs
StatePublished - 1 Jan 2014

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Coccidioides
Coccidioidomycosis
Epidemiology
Fungi
Genetic Speciation
Molecular Epidemiology
Genetic Structures
Mexico
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Molecular Biology
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Cite this

Duarte-Escalante, E., Frías-De-León, M. G., Zúñiga, G., Martínez-Herrera, E., Acosta-Altamirano, G., & Reyes-Montes, M. D. R. (2014). Molecular markers in the epidemiology and diagnosis of coccidioidomycosis. Revista Iberoamericana de Micologia, 49-53. https://doi.org/10.1016/j.riam.2013.09.011
Duarte-Escalante, Esperanza ; Frías-De-León, María Guadalupe ; Zúñiga, Gerardo ; Martínez-Herrera, Erick ; Acosta-Altamirano, Gustavo ; Reyes-Montes, María del Rocío. / Molecular markers in the epidemiology and diagnosis of coccidioidomycosis. In: Revista Iberoamericana de Micologia. 2014 ; pp. 49-53.
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Duarte-Escalante, E, Frías-De-León, MG, Zúñiga, G, Martínez-Herrera, E, Acosta-Altamirano, G & Reyes-Montes, MDR 2014, 'Molecular markers in the epidemiology and diagnosis of coccidioidomycosis', Revista Iberoamericana de Micologia, pp. 49-53. https://doi.org/10.1016/j.riam.2013.09.011

Molecular markers in the epidemiology and diagnosis of coccidioidomycosis. / Duarte-Escalante, Esperanza; Frías-De-León, María Guadalupe; Zúñiga, Gerardo; Martínez-Herrera, Erick; Acosta-Altamirano, Gustavo; Reyes-Montes, María del Rocío.

In: Revista Iberoamericana de Micologia, 01.01.2014, p. 49-53.

Research output: Contribution to journalShort survey

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T1 - Molecular markers in the epidemiology and diagnosis of coccidioidomycosis

AU - Duarte-Escalante, Esperanza

AU - Frías-De-León, María Guadalupe

AU - Zúñiga, Gerardo

AU - Martínez-Herrera, Erick

AU - Acosta-Altamirano, Gustavo

AU - Reyes-Montes, María del Rocío

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N2 - The prevalence of coccidioidomycosis in endemic areas has been observed to increase daily. To understand the causes of the spread of the disease and design strategies for fungal detection in clinical and environmental samples, scientists have resorted to molecular tools that allow fungal detection in a natural environment, reliable identification in clinical cases and the study of biological characteristics, such as reproductive and genetic structure, demographic history and diversification. We conducted a review of the most important molecular markers in the epidemiology of Coccidioides spp. and the diagnosis of coccidioidomycosis. A literature search was performed for scientific publications concerning the application of molecular tools for the epidemiology and diagnosis of coccidioidomycosis. The use of molecular markers in the epidemiological study and diagnosis of coccidioidomycosis has allowed for the typing of Coccidioides spp. isolates, improved understanding of their mode of reproduction, genetic variation and speciation and resulted in the development specific, rapid and sensitive strategies for detecting the fungus in environmental and clinical samples. Molecular markers have revealed genetic variability in Coccidioides spp. This finding influences changes in the epidemiology of coccidioidomycosis, such as the emergence of more virulent or antifungal resistant genotypes. Furthermore, the molecular markers currently used to identify Coccidioides immitis and Coccidioides posadasii are specific and sensitive. However, they must be validated to determine their application in diagnosis.This manuscript is part of the series of works presented at the "V International Workshop: Molecular genetic approaches to the study of human pathogenic fungi" (Oaxaca, Mexico, 2012). © 2013 Revista Iberoamericana de Micología.

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Duarte-Escalante E, Frías-De-León MG, Zúñiga G, Martínez-Herrera E, Acosta-Altamirano G, Reyes-Montes MDR. Molecular markers in the epidemiology and diagnosis of coccidioidomycosis. Revista Iberoamericana de Micologia. 2014 Jan 1;49-53. https://doi.org/10.1016/j.riam.2013.09.011