Molecular events by which dendritic cells promote Th2 immune protection in helmith infection

Research output: Contribution to journalScientific reviewResearchpeer-review

2 Citations (Scopus)

Abstract

© 2016 Society for Scandinavian Journal of Infectious Diseases. Abstract: Helminth parasites are a major cause of global infectious diseases, affecting nearly one quarter of the world's population. The common feature of helminth infections is to skew the immune system towards a T-helper 2 (Th2) response that helps to control disease. Dendritic cells (DCs), which are professional antigen-presenting cells, play a critical role for Th2 skewing against helminth parasites. However, the molecular mechanisms by which helminth antigens activate DCs for Th2 polarization have not yet been clearly defined. This review provides a focused update on the major role of DCs for inducing and/or enhancing Th2 immune responses in helminthic infection and will discuss the main signalling-dependent and independent mechanisms by which helminth antigens activate DCs for Th2 skewing.
Original languageAmerican English
Pages (from-to)715-720
Number of pages642
JournalInfectious Diseases
DOIs
StatePublished - 2 Oct 2016

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infectious diseases
Dendritic Cells
Helminth Antigens
Helminths
antigens
Antigens
parasites
Infection
cells
Communicable Diseases
Parasites
Disease control
Immune system
Antigen-Presenting Cells
immune systems
Immune System
Polarization
Population
causes
polarization

Cite this

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title = "Molecular events by which dendritic cells promote Th2 immune protection in helmith infection",
abstract = "{\circledC} 2016 Society for Scandinavian Journal of Infectious Diseases. Abstract: Helminth parasites are a major cause of global infectious diseases, affecting nearly one quarter of the world's population. The common feature of helminth infections is to skew the immune system towards a T-helper 2 (Th2) response that helps to control disease. Dendritic cells (DCs), which are professional antigen-presenting cells, play a critical role for Th2 skewing against helminth parasites. However, the molecular mechanisms by which helminth antigens activate DCs for Th2 polarization have not yet been clearly defined. This review provides a focused update on the major role of DCs for inducing and/or enhancing Th2 immune responses in helminthic infection and will discuss the main signalling-dependent and independent mechanisms by which helminth antigens activate DCs for Th2 skewing.",
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Molecular events by which dendritic cells promote Th2 immune protection in helmith infection. / Méndez-Samperio, Patricia.

In: Infectious Diseases, 02.10.2016, p. 715-720.

Research output: Contribution to journalScientific reviewResearchpeer-review

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