Abstract
Abstract: Helminth parasites are a major cause of global infectious diseases, affecting nearly one quarter of the world's population. The common feature of helminth infections is to skew the immune system towards a T-helper 2 (Th2) response that helps to control disease. Dendritic cells (DCs), which are professional antigen-presenting cells, play a critical role for Th2 skewing against helminth parasites. However, the molecular mechanisms by which helminth antigens activate DCs for Th2 polarization have not yet been clearly defined. This review provides a focused update on the major role of DCs for inducing and/or enhancing Th2 immune responses in helminthic infection and will discuss the main signalling-dependent and independent mechanisms by which helminth antigens activate DCs for Th2 skewing.
Original language | English |
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Pages (from-to) | 715-720 |
Number of pages | 6 |
Journal | Infectious Diseases |
Volume | 48 |
Issue number | 10 |
DOIs | |
State | Published - 2 Oct 2016 |
Keywords
- Dendritic cells
- helminths
- type-2 response