TY - JOUR
T1 - Modular analysis of the transcriptional regulatory network of E. coli
AU - Resendis-Antonio, Osbaldo
AU - Freyre-González, Julio A.
AU - Menchaca-Méndez, Ricardo
AU - Gutiérrez-Ríos, Rosa M.
AU - Martínez-Antonio, Agustino
AU - Ávila-Sánchez, Cristhian
AU - Collado-Vides, Julio
N1 - Funding Information:
J.F-G. is supported by Ph.D. fellowship 176341 from CONACyT-Mexico. This work is supported by grant GM 62205-03 from NIH to J.C-V. We thank Verónica Jiménez for help extracting the dataset from RegulonDB. We also acknowledge Fabiola Sánchez for her computing support. We acknowledge the Editor for helping to improve this article.
PY - 2005/1
Y1 - 2005/1
N2 - The transcriptional network of Escherichia coli is currently the best-understood regulatory network of a single cell. Motivated by statistical evidence, suggesting a hierarchical modular architecture in this network, we identified eight modules with well-defined physiological functions. These modules were identified by a clustering approach, using the shortest path to trace regulatory relationships across genes in the network. We report the type (feed forward and bifan) and distribution of motifs between and within modules. Feed-forward motifs tend to be embedded within modules, whereas bi-fan motifs tend to link modules, supporting the notion of a hierarchical network with defined functional modules.
AB - The transcriptional network of Escherichia coli is currently the best-understood regulatory network of a single cell. Motivated by statistical evidence, suggesting a hierarchical modular architecture in this network, we identified eight modules with well-defined physiological functions. These modules were identified by a clustering approach, using the shortest path to trace regulatory relationships across genes in the network. We report the type (feed forward and bifan) and distribution of motifs between and within modules. Feed-forward motifs tend to be embedded within modules, whereas bi-fan motifs tend to link modules, supporting the notion of a hierarchical network with defined functional modules.
UR - http://www.scopus.com/inward/record.url?scp=13144283679&partnerID=8YFLogxK
U2 - 10.1016/j.tig.2004.11.010
DO - 10.1016/j.tig.2004.11.010
M3 - Estudio breve
SN - 0168-9525
VL - 21
SP - 16
EP - 20
JO - Trends in Genetics
JF - Trends in Genetics
IS - 1
ER -