Modifications on the tetrahydroquinoline scaffold targeting a phenylalanine cluster on GPER as antiproliferative compounds against renal, liver and pancreatic cancer cells

Medicine & Life Sciences

• 1,2,3,4-tetrahydroquinoline 100%
• Kidney Neoplasms 60%
• Phenylalanine 58%
• G-Protein-Coupled Receptors 53%
• Liver Neoplasms 53%
• Pancreatic Neoplasms 50%
• Estrogen Receptors 49%
• Binding Sites 17%
• Computer Simulation 14%
• Cuniculidae 13%
• Growth 11%
• thiazolyl blue 9%
• Molecular Dynamics Simulation 8%
• Mechanics 7%
• Neoplasms 7%
• Computational Biology 7%
• Ligands 5%
• Cell Line 4%
• Pharmaceutical Preparations 3%

Chemistry

• Estrogen 57%
• Phenylalanine 53%
• Antiproliferative 53%
• Molecular Cluster 34%
• Modification 29%
• Binding Site 16%
• 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium Bromide 9%
• Molecular Recognition 7%
• Molecular Mechanic 7%
• Agonist 7%
• Antagonist 7%
• Pharmacological Metabolism 5%
• Molecular Dynamics 5%
• Molecule 5%
• Surface Area 4%
• Simulation 4%
• Drug 4%
• Ligand 3%