TY - JOUR
T1 - Moderate exercise prevents the cell atrophy caused by hypothyroidism in rats
AU - Martínez-Salazar, Carmen
AU - Villanueva, Iván
AU - Pacheco-Rosado, Jorge
AU - Alva-Sánchez, Claudia
N1 - Publisher Copyright:
© 2020, Nencki Institute of Experimental Biology. All rights reserved.
PY - 2020
Y1 - 2020
N2 - Adult-onset hypothyroidism is associated with an increase in cell atrophy of the hippocampal pyramidal neurons. Physical exercise implies diverse actions on the neural tissue that promote neuron proliferation and survival. The beneficial effects of exercise seem to be inversely linked to its intensity, so that strenuous exercise has reduced protective effects. In this study we evaluated the capacity of a moderate forced-exercise routine to counteract the neurodegenerative effects of a hypothyroid condition induced during adulthood. Simultaneously with a chronic anti-thyroid chemical treatment, a group of rats was forced to walk in a motorized wheel for 30 min daily five times a week. In four weeks of treatment the rats developed a plain hypothyroid condition that in non-exercised rats was accompanied by a marked increase in the number of atrophic cells in all CA regions of the hippocampus. The forced-exercise treatment did not counter the development of hypothyroidism and its signs, but it did prevent almost completely the associated neuronal damage in all CA regions. The forced exercise also improved the cognitive function in a spatial-learning test. These results indicate that moderate exercise has the potential to prevent the structural and functional deficits associated with a hypothyroid condition.
AB - Adult-onset hypothyroidism is associated with an increase in cell atrophy of the hippocampal pyramidal neurons. Physical exercise implies diverse actions on the neural tissue that promote neuron proliferation and survival. The beneficial effects of exercise seem to be inversely linked to its intensity, so that strenuous exercise has reduced protective effects. In this study we evaluated the capacity of a moderate forced-exercise routine to counteract the neurodegenerative effects of a hypothyroid condition induced during adulthood. Simultaneously with a chronic anti-thyroid chemical treatment, a group of rats was forced to walk in a motorized wheel for 30 min daily five times a week. In four weeks of treatment the rats developed a plain hypothyroid condition that in non-exercised rats was accompanied by a marked increase in the number of atrophic cells in all CA regions of the hippocampus. The forced-exercise treatment did not counter the development of hypothyroidism and its signs, but it did prevent almost completely the associated neuronal damage in all CA regions. The forced exercise also improved the cognitive function in a spatial-learning test. These results indicate that moderate exercise has the potential to prevent the structural and functional deficits associated with a hypothyroid condition.
KW - Hippocampus
KW - Hypothyroidism
KW - Moderate exercise
KW - Neural atrophy
KW - Neuroprotection
UR - http://www.scopus.com/inward/record.url?scp=85082464655&partnerID=8YFLogxK
U2 - 10.21307/ane-2020-005
DO - 10.21307/ane-2020-005
M3 - Artículo
C2 - 32214274
AN - SCOPUS:85082464655
SN - 0065-1400
VL - 80
SP - 47
EP - 56
JO - Acta Neurobiologiae Experimentalis
JF - Acta Neurobiologiae Experimentalis
IS - 1
ER -