TY - JOUR
T1 - Modeling dendritic cell pulsed immunotherapy for mice with melanoma-protocols for success and recurrence
AU - Chimal-Eguia, Juan Carlos
AU - Castillo-Montiel, Erandi
AU - Rangel-Reyes, Julio Cesar
AU - Paez-Hernández, Ricardo Teodoro
N1 - Publisher Copyright:
© 2021 by the authors.
PY - 2021/4/1
Y1 - 2021/4/1
N2 - Nowadays, immunotherapy has become an important alternative to fight cancer. One way in which biologists and medics use immunotherapy is by injecting antigen-incubated Dendritic Cells (DCs) into mice to stimulate an immune response. The DCs optimal quantities and infusion times for a successful cancer eradication are often unknown to the therapists; usually, these quantities are obtained by testing various protocols. The article shows a model of five differential equations which represents some interactions between some cells of the immune system and tumor cells which is used to test different infusion protocols of Dendritic Cells. This study aims to find operation ranges to DCs quantities and injection times for which the therapy reduces the tumor significantly. To that end, an exhaustive search of operative protocols is performed using simulations of a mathematical model. Furthermore, nonlinear analysis of the model reveals that without the DC therapy tumor cells cannot stay under non-lethal bounds. Finally, we show that a pulsed periodic therapy can prevent tumor relapsing when the doses and period times lie within a certain range.
AB - Nowadays, immunotherapy has become an important alternative to fight cancer. One way in which biologists and medics use immunotherapy is by injecting antigen-incubated Dendritic Cells (DCs) into mice to stimulate an immune response. The DCs optimal quantities and infusion times for a successful cancer eradication are often unknown to the therapists; usually, these quantities are obtained by testing various protocols. The article shows a model of five differential equations which represents some interactions between some cells of the immune system and tumor cells which is used to test different infusion protocols of Dendritic Cells. This study aims to find operation ranges to DCs quantities and injection times for which the therapy reduces the tumor significantly. To that end, an exhaustive search of operative protocols is performed using simulations of a mathematical model. Furthermore, nonlinear analysis of the model reveals that without the DC therapy tumor cells cannot stay under non-lethal bounds. Finally, we show that a pulsed periodic therapy can prevent tumor relapsing when the doses and period times lie within a certain range.
KW - Biological system modeling
KW - Differential equations
KW - Immunotherapy
KW - Nonlinear analysis
UR - http://www.scopus.com/inward/record.url?scp=85104064124&partnerID=8YFLogxK
U2 - 10.3390/app11073199
DO - 10.3390/app11073199
M3 - Artículo
AN - SCOPUS:85104064124
SN - 2076-3417
VL - 11
JO - Applied Sciences (Switzerland)
JF - Applied Sciences (Switzerland)
IS - 7
M1 - 3199
ER -