TY - JOUR
T1 - Milk intake and IGF-1 rs6214 polymorphism as protective factors to obesity
AU - Grijalva-Avila, Julio
AU - Villanueva-Fierro, Ignacio
AU - Lares-Asseff, Ismael
AU - Chairez-Hernández, Isaías
AU - Rivera-Sanchez, Gildardo
AU - Martínez-Estrada, Sandra
AU - Martínez-Rivera, Israel
AU - Quiñones, Luis A.
AU - Loera-Castañeda, Verónica
N1 - Publisher Copyright:
© 2019, © 2019 Taylor & Francis Group, LLC.
PY - 2020/4/2
Y1 - 2020/4/2
N2 - Mexico ranks 2nd in adult obesity and 4th in milk intake worldwide. Low levels of IGF-1 have been related to obesity and can be reverted by milk intake. The rs6214 polymorphism has been associated with an increase in the expression of IGF-1. Therefore, the aim of the study was to evaluate the association between both, rs6214 polymorphism and milk intake, and obesity. We analysed 99 adult volunteers, with and without a history of milk intake, for the presence of this polymorphism through qPCR and body composition by electro-bioimpedance. Univariate logistic regression analyses showed that TT genotype is inversely associated with obesity and body fat mass. Besides, milk intake is also related to low obesity, body fat mass and visceral fat, and high percentage of lean mass. Multivariate logistic regression analyses confirm the univariate relationships, showing a clear inverted association between TT genotype, milk intake and obesity.
AB - Mexico ranks 2nd in adult obesity and 4th in milk intake worldwide. Low levels of IGF-1 have been related to obesity and can be reverted by milk intake. The rs6214 polymorphism has been associated with an increase in the expression of IGF-1. Therefore, the aim of the study was to evaluate the association between both, rs6214 polymorphism and milk intake, and obesity. We analysed 99 adult volunteers, with and without a history of milk intake, for the presence of this polymorphism through qPCR and body composition by electro-bioimpedance. Univariate logistic regression analyses showed that TT genotype is inversely associated with obesity and body fat mass. Besides, milk intake is also related to low obesity, body fat mass and visceral fat, and high percentage of lean mass. Multivariate logistic regression analyses confirm the univariate relationships, showing a clear inverted association between TT genotype, milk intake and obesity.
KW - BMI
KW - IGF-1
KW - obesity
KW - rs6214
UR - http://www.scopus.com/inward/record.url?scp=85073970931&partnerID=8YFLogxK
U2 - 10.1080/09637486.2019.1666805
DO - 10.1080/09637486.2019.1666805
M3 - Artículo
C2 - 31530040
AN - SCOPUS:85073970931
SN - 0963-7486
VL - 71
SP - 388
EP - 393
JO - International Journal of Food Sciences and Nutrition
JF - International Journal of Food Sciences and Nutrition
IS - 3
ER -
