TY - JOUR
T1 - Microvascular protective activity in rabbits of triterpenes from Hylocereus undatus
AU - Gutiérrez, Rosa Martha Pérez
AU - Solís, Rosario Vargas
AU - Baez, Efren García
AU - Flores, Jose María Mota
PY - 2007/7
Y1 - 2007/7
N2 - Two new pentacyclic triterpene taraxast-20-ene-3α-ol (1) and taraxast-12,20(30)-dien-3α-ol (2) were isolated from chloroform extract of leaves of Hylocereus undatus. These triterpenes showed protective activity against the increase of skin vascular permeability in rabbits. The protective effect, measured as the reduction in leakage of Evans blue, was of 53.5% and 70.1% for 1 and 2, respectively, after peritoneal treatment at a dose of 50 mg/kg. Comparison was made between the action of the compounds and a protective microvascular drug known as troxerutin (64.5%) at the same doses.
AB - Two new pentacyclic triterpene taraxast-20-ene-3α-ol (1) and taraxast-12,20(30)-dien-3α-ol (2) were isolated from chloroform extract of leaves of Hylocereus undatus. These triterpenes showed protective activity against the increase of skin vascular permeability in rabbits. The protective effect, measured as the reduction in leakage of Evans blue, was of 53.5% and 70.1% for 1 and 2, respectively, after peritoneal treatment at a dose of 50 mg/kg. Comparison was made between the action of the compounds and a protective microvascular drug known as troxerutin (64.5%) at the same doses.
KW - Hylocereus undatus
KW - Taraxast-12,20(30)-dien-3α-ol
KW - Taraxast-20-ene-3α-ol
KW - Taraxastane triterpenes
UR - http://www.scopus.com/inward/record.url?scp=34548845044&partnerID=8YFLogxK
U2 - 10.1007/s11418-007-0150-y
DO - 10.1007/s11418-007-0150-y
M3 - Artículo
SN - 1340-3443
VL - 61
SP - 296
EP - 301
JO - Journal of Natural Medicines
JF - Journal of Natural Medicines
IS - 3
ER -