TY - JOUR
T1 - Medical outcomes in women who became pregnant after vaccination with a virus-like particle experimental vaccine against influenza A (H1N1) 2009 virus tested during 2009 pandemic outbreak
AU - Cérbulo-Vázquez, Arturo
AU - Arriaga-Pizano, Lourdes
AU - Cruz-Cureño, Gabriela
AU - Boscó-Gárate, Ilka
AU - Ferat-Osorio, Eduardo
AU - Pastelin-Palacios, Rodolfo
AU - Figueroa-Damian, Ricardo
AU - Castro-Eguiluz, Denisse
AU - Mancilla-Ramirez, Javier
AU - Isibasi, Armando
AU - López-Macías, Constantino
N1 - Publisher Copyright:
© 2019 by the authors.
PY - 2019/9/17
Y1 - 2019/9/17
N2 - The clinical effects and immunological response to the influenza vaccine in women who later become pregnant remain to be thoroughly studied. Here, we report the medical outcomes of 40 women volunteers who became pregnant after vaccination with an experimental virus-like particle (VLP) vaccine against pandemic influenza A(H1N1)2009 (influenza A(H1N1)pdm09) and their infants. When included in the VLP vaccine trial, none of the women were pregnant and were randomly assigned to one of the following groups: (1) placebo, (2) 15 µg dose of VLP vaccine, or (3) 45 µg dose of VLP vaccine. These 40 women reported becoming pregnant during the follow-up phase after receiving the placebo or VLP vaccine. Women were monitored throughout pregnancy and their infants were monitored until one year after birth. Antibody titers against VLP were measured in the mothers and infants at delivery and at six months and one year after birth. The incidence of preeclampsia, fetal death, preterm delivery, and premature rupture of membranes was similar among groups. All vaccinated women and their infants elicited antibody titers (≥1:40). Women vaccinated prior to pregnancy had no adverse events that were different from the nonvaccinated population. Even though this study is limited by the sample size, the results suggest that the anti-influenza A(H1N1)pdm09 VLP experimental vaccine applied before pregnancy is safe for both mothers and their infants.
AB - The clinical effects and immunological response to the influenza vaccine in women who later become pregnant remain to be thoroughly studied. Here, we report the medical outcomes of 40 women volunteers who became pregnant after vaccination with an experimental virus-like particle (VLP) vaccine against pandemic influenza A(H1N1)2009 (influenza A(H1N1)pdm09) and their infants. When included in the VLP vaccine trial, none of the women were pregnant and were randomly assigned to one of the following groups: (1) placebo, (2) 15 µg dose of VLP vaccine, or (3) 45 µg dose of VLP vaccine. These 40 women reported becoming pregnant during the follow-up phase after receiving the placebo or VLP vaccine. Women were monitored throughout pregnancy and their infants were monitored until one year after birth. Antibody titers against VLP were measured in the mothers and infants at delivery and at six months and one year after birth. The incidence of preeclampsia, fetal death, preterm delivery, and premature rupture of membranes was similar among groups. All vaccinated women and their infants elicited antibody titers (≥1:40). Women vaccinated prior to pregnancy had no adverse events that were different from the nonvaccinated population. Even though this study is limited by the sample size, the results suggest that the anti-influenza A(H1N1)pdm09 VLP experimental vaccine applied before pregnancy is safe for both mothers and their infants.
KW - Antibody titers
KW - Influenza A(H1N1)pdm09
KW - Pregnant women
KW - Vaccination
KW - Virus-like particle
UR - http://www.scopus.com/inward/record.url?scp=85072402388&partnerID=8YFLogxK
U2 - 10.3390/v11090868
DO - 10.3390/v11090868
M3 - Artículo
C2 - 31533277
AN - SCOPUS:85072402388
SN - 1999-4915
VL - 11
JO - Viruses
JF - Viruses
IS - 9
M1 - 868
ER -