Mechanisms of Cell Volume Regulation in Hypo-osmolality

Herminia Pasantes-Morales, Ruth A. Lezama, Gerardo Ramos-Mandujano, Karina L. Tuz

Research output: Contribution to journalArticleResearchpeer-review

103 Citations (Scopus)

Abstract

Cells respond to a condition of hypo-osmolality by rapid swelling followed by an adaptive response that tends to recover the normal cell volume despite the persistence of the hypo-osmotic condition. This is an active process accomplished by the extrusion of intracellular osmolytes, essentially K+, Cl-, and small organic molecules. This regulatory process operates through a chain of events that essentially consists of a sensor or sensing mechanism to detect changes in cell volume, a signaling cascade to amplify the sensing signal and orient it to activate pathways for osmolyte extrusion, and a memory of the original cell volume, which sets the timing for inactivation of the volume-regulatory process. This article presents a brief overview of recent progress in these different aspects of the volume-regulatory process, including (1) the mechanisms and/or candidate molecules serving the role of volume sensors, (2) the osmosignaling network and the interplay and hierarchy of the different elements in this chain, and (3) the nature and properties of the osmolyte extrusion pathways. Emphasis is placed on some of the main unsolved questions concerning different aspects of the volume-regulatory process. Recent findings regarding the effect of hypo-osmolality on synaptic function are briefly discussed in terms of the possible molecular basis for the neurologic symptoms induced by hyponatremia. © 2006 Elsevier Inc. All rights reserved.
Original languageAmerican English
JournalAmerican Journal of Medicine
DOIs
StatePublished - 1 Jul 2006
Externally publishedYes

Fingerprint

Cell Size
Osmolar Concentration
Extrusion
cells
Molecules
Hyponatremia
Sensors
Neurologic Manifestations
Swelling
Data storage equipment
sensors
swelling
deactivation
hierarchies
molecules
cascades
time measurement

Cite this

Pasantes-Morales, Herminia ; Lezama, Ruth A. ; Ramos-Mandujano, Gerardo ; Tuz, Karina L. / Mechanisms of Cell Volume Regulation in Hypo-osmolality. In: American Journal of Medicine. 2006.
@article{d4c389dc9cb14c32b8de56a242ae5868,
title = "Mechanisms of Cell Volume Regulation in Hypo-osmolality",
abstract = "Cells respond to a condition of hypo-osmolality by rapid swelling followed by an adaptive response that tends to recover the normal cell volume despite the persistence of the hypo-osmotic condition. This is an active process accomplished by the extrusion of intracellular osmolytes, essentially K+, Cl-, and small organic molecules. This regulatory process operates through a chain of events that essentially consists of a sensor or sensing mechanism to detect changes in cell volume, a signaling cascade to amplify the sensing signal and orient it to activate pathways for osmolyte extrusion, and a memory of the original cell volume, which sets the timing for inactivation of the volume-regulatory process. This article presents a brief overview of recent progress in these different aspects of the volume-regulatory process, including (1) the mechanisms and/or candidate molecules serving the role of volume sensors, (2) the osmosignaling network and the interplay and hierarchy of the different elements in this chain, and (3) the nature and properties of the osmolyte extrusion pathways. Emphasis is placed on some of the main unsolved questions concerning different aspects of the volume-regulatory process. Recent findings regarding the effect of hypo-osmolality on synaptic function are briefly discussed in terms of the possible molecular basis for the neurologic symptoms induced by hyponatremia. {\circledC} 2006 Elsevier Inc. All rights reserved.",
author = "Herminia Pasantes-Morales and Lezama, {Ruth A.} and Gerardo Ramos-Mandujano and Tuz, {Karina L.}",
year = "2006",
month = "7",
day = "1",
doi = "10.1016/j.amjmed.2006.05.002",
language = "American English",
journal = "American Journal of Medicine",
issn = "0002-9343",
publisher = "Elsevier Inc.",

}

Mechanisms of Cell Volume Regulation in Hypo-osmolality. / Pasantes-Morales, Herminia; Lezama, Ruth A.; Ramos-Mandujano, Gerardo; Tuz, Karina L.

In: American Journal of Medicine, 01.07.2006.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Mechanisms of Cell Volume Regulation in Hypo-osmolality

AU - Pasantes-Morales, Herminia

AU - Lezama, Ruth A.

AU - Ramos-Mandujano, Gerardo

AU - Tuz, Karina L.

PY - 2006/7/1

Y1 - 2006/7/1

N2 - Cells respond to a condition of hypo-osmolality by rapid swelling followed by an adaptive response that tends to recover the normal cell volume despite the persistence of the hypo-osmotic condition. This is an active process accomplished by the extrusion of intracellular osmolytes, essentially K+, Cl-, and small organic molecules. This regulatory process operates through a chain of events that essentially consists of a sensor or sensing mechanism to detect changes in cell volume, a signaling cascade to amplify the sensing signal and orient it to activate pathways for osmolyte extrusion, and a memory of the original cell volume, which sets the timing for inactivation of the volume-regulatory process. This article presents a brief overview of recent progress in these different aspects of the volume-regulatory process, including (1) the mechanisms and/or candidate molecules serving the role of volume sensors, (2) the osmosignaling network and the interplay and hierarchy of the different elements in this chain, and (3) the nature and properties of the osmolyte extrusion pathways. Emphasis is placed on some of the main unsolved questions concerning different aspects of the volume-regulatory process. Recent findings regarding the effect of hypo-osmolality on synaptic function are briefly discussed in terms of the possible molecular basis for the neurologic symptoms induced by hyponatremia. © 2006 Elsevier Inc. All rights reserved.

AB - Cells respond to a condition of hypo-osmolality by rapid swelling followed by an adaptive response that tends to recover the normal cell volume despite the persistence of the hypo-osmotic condition. This is an active process accomplished by the extrusion of intracellular osmolytes, essentially K+, Cl-, and small organic molecules. This regulatory process operates through a chain of events that essentially consists of a sensor or sensing mechanism to detect changes in cell volume, a signaling cascade to amplify the sensing signal and orient it to activate pathways for osmolyte extrusion, and a memory of the original cell volume, which sets the timing for inactivation of the volume-regulatory process. This article presents a brief overview of recent progress in these different aspects of the volume-regulatory process, including (1) the mechanisms and/or candidate molecules serving the role of volume sensors, (2) the osmosignaling network and the interplay and hierarchy of the different elements in this chain, and (3) the nature and properties of the osmolyte extrusion pathways. Emphasis is placed on some of the main unsolved questions concerning different aspects of the volume-regulatory process. Recent findings regarding the effect of hypo-osmolality on synaptic function are briefly discussed in terms of the possible molecular basis for the neurologic symptoms induced by hyponatremia. © 2006 Elsevier Inc. All rights reserved.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33745698361&origin=inward

UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=33745698361&origin=inward

U2 - 10.1016/j.amjmed.2006.05.002

DO - 10.1016/j.amjmed.2006.05.002

M3 - Article

JO - American Journal of Medicine

JF - American Journal of Medicine

SN - 0002-9343

ER -