TY - JOUR
T1 - Mast cells in lung homeostasis
T2 - Beyond type I hypersensitivity
AU - Campillo-Navarro, Marcia
AU - Chávez-Blanco, Alma D.
AU - Wong-Baeza, Isabel
AU - Serafín-López, Jeanet
AU - Flores-Mejía, Raúl
AU - Estrada-Parra, Sergio
AU - Estrada-García, Iris
AU - Chacón-Salinas, Rommel
N1 - Publisher Copyright:
© 2014 Bentham Science Publishers.
PY - 2014
Y1 - 2014
N2 - Lungs are indispensable organs for the respiratory process, and maintaining their homeostasis is essential for human health and survival. However, during the lifetime of an individual, the lungs suffer countless insults that put at risk their delicate organization and function. Many cells of the immune system participate to maintain this equilibrium and to keep functional lungs. Among these cells, mast cells have recently attracted attention because of their ability to rapidly secrete many chemical and biological mediators that modulate different processes like inflammation, angiogenesis, cell proliferation, etc. In this review, we focus on recent advances in the understanding of the role that mast cells play in lung protection during infections, and of the relation of mast cell responses to type I hypersensitivity-associated pathologies.
AB - Lungs are indispensable organs for the respiratory process, and maintaining their homeostasis is essential for human health and survival. However, during the lifetime of an individual, the lungs suffer countless insults that put at risk their delicate organization and function. Many cells of the immune system participate to maintain this equilibrium and to keep functional lungs. Among these cells, mast cells have recently attracted attention because of their ability to rapidly secrete many chemical and biological mediators that modulate different processes like inflammation, angiogenesis, cell proliferation, etc. In this review, we focus on recent advances in the understanding of the role that mast cells play in lung protection during infections, and of the relation of mast cell responses to type I hypersensitivity-associated pathologies.
KW - Allergic inflammation
KW - Cancer
KW - Lungs
KW - Mast cells
KW - Pathogens
KW - Wound healing
UR - http://www.scopus.com/inward/record.url?scp=84930901660&partnerID=8YFLogxK
U2 - 10.2174/1573398X10666141024220151
DO - 10.2174/1573398X10666141024220151
M3 - Artículo
C2 - 25484639
SN - 1573-398X
VL - 10
SP - 115
EP - 123
JO - Current Respiratory Medicine Reviews
JF - Current Respiratory Medicine Reviews
IS - 2
ER -