Las plantas medicinales Mexicanas como fuente de compuestos antimicobacterianos

Translated title of the contribution: Mexican medicinal plants as a source of antimycobacterial compounds

María Adelina Jiménez Arellanes, Jorge Cornejo Garrido, Rosalba León Díaz

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Ca. 75 species from Mexican medicinal flora have been tested in vitro against Mycobacterium tuberculosis H37Rv. Some of these were selected based on their medicinal uses. The most active species include Phoradendron robinsonii, Larrea divericata, Amphiteryngium adstringens, Buddleja cordata, Piper sanctum, Arracacia tolucensis, Carya illinoiensis, Diospyros anisandra, and Thymus vulgaris. A number of active compounds isolated from medicinal plants by bioguided fractionation are 2-oxo-14-(3′,4′-methylenedioxyphenyl) tetradecane, 2-oxo-16-(3′,4′-methylenedioxyphenyl)-hexadecane, 5,6-dehydro-7,8-dihydromethysticin, cepharanone B, piperolactam A, suberosin, escobarine A, oleanolic acid, ursolic acid, the mixture of these two latter compounds (ursolic/oleanolic acids), and E and Z-phytols with minimal inhibitory concentration (MIC) < 25 μg/mL against M. tuberculosis H37Rv. Also some macrolactones glycolipids isolated from Ipomoea genus demonstrated important antimycobacterial activity against M. tuberculosis H37Rv (MIC < 32 μg/mL). Other secondary metabolites with antimycobacterial activity were six alkaloids, two flavonoids, two quinones and two triterpenes (MIC < 25 μg/mL).

Translated title of the contributionMexican medicinal plants as a source of antimycobacterial compounds
Original languageFrench
Pages (from-to)22-29
Number of pages8
JournalRevista Mexicana de Ciencias Farmaceuticas
Volume41
Issue number1
StatePublished - Jan 2010
Externally publishedYes

Keywords

  • Antimycobacterial compounds
  • Medicinal plants
  • Mycobacterium tuberculosis

Fingerprint

Dive into the research topics of 'Mexican medicinal plants as a source of antimycobacterial compounds'. Together they form a unique fingerprint.

Cite this