TY - JOUR
T1 - La metformina incrementa la concentración sérica de adiponectina de alto peso molecular (adiponectina-hmw) en obesos no diabéticos
AU - García García, José Antonio
AU - Lara Padilla, Eleazar
AU - Álvarez Hernández, Everardo
AU - Ocharán Hernández, María Esther
AU - Gutiérrez Iglesias, Gisela
AU - Melendro Lozano, Emma Isabel
AU - Amancio Chasin, Octavio
AU - Sánchez Pedraza, Valentín
AU - Hernández Ruiz, Joselín
AU - López Alvarenga, Juan Carlos
PY - 2014
Y1 - 2014
N2 - Introduction: Obesity is associated with low-intensity chronic systemic inflammation. Objective: To evaluate the efficacy of two different doses of metformin in comparison with placebo on increased serum levels of high molecular weight (HMW) adiponectin. Material and methods: An experimental design was developed with a crossover complete treatment and balanced design; 28 female and eight male nondiabetic obese adults participated. All participants received, during a week and in randomized order: placebo or metformin 500 or 850 mg twice daily; there was a week washout period between each treatment. The HMW adiponectin serum concentration (0 and 120 minutes) at the end of each treatment was measured. Analyses of variance (ANOVA), Bonferroni test, and size effect calculations were performed. Results: Differences in concentrations of HMW adiponectin (t0', t120') were measured for each treatment by ANOVA, having values of p = 0.03 and 0.002, respectively. The post hoc analysis reported differences favoring treatment with metformin 850 mg (p = 0.025). The sizes of the effect at times t0 and t120 for metformin 500 mg were 34 and 35%, and for metformin 850 mg, 65 and 84%, respectively.
AB - Introduction: Obesity is associated with low-intensity chronic systemic inflammation. Objective: To evaluate the efficacy of two different doses of metformin in comparison with placebo on increased serum levels of high molecular weight (HMW) adiponectin. Material and methods: An experimental design was developed with a crossover complete treatment and balanced design; 28 female and eight male nondiabetic obese adults participated. All participants received, during a week and in randomized order: placebo or metformin 500 or 850 mg twice daily; there was a week washout period between each treatment. The HMW adiponectin serum concentration (0 and 120 minutes) at the end of each treatment was measured. Analyses of variance (ANOVA), Bonferroni test, and size effect calculations were performed. Results: Differences in concentrations of HMW adiponectin (t0', t120') were measured for each treatment by ANOVA, having values of p = 0.03 and 0.002, respectively. The post hoc analysis reported differences favoring treatment with metformin 850 mg (p = 0.025). The sizes of the effect at times t0 and t120 for metformin 500 mg were 34 and 35%, and for metformin 850 mg, 65 and 84%, respectively.
KW - Experimental design
KW - High molecular weight adiponectin
KW - Metformin
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=84906508508&partnerID=8YFLogxK
M3 - Artículo
SN - 0016-3813
VL - 150
SP - 324
EP - 333
JO - Gaceta Medica de Mexico
JF - Gaceta Medica de Mexico
IS - 4
ER -