L-carnitine supplementation in duchenne muscular dystrophy steroid-naïve patients: A pilot study

Rosa E. Escobar-Cedillo, Jesús A. Tintos-Hernández, Guadalupe Martińez-Castro, Beatriz Montes De Oca-Sańchez, Rodolfo Rodriǵuez-Jurado, Antonio Miranda-Duarte, Socorro Lona-Pimentel, Benjamín Gómez-D́iaz, Ramón M. Coral-Vázquez, Silvia Garciá, Luz Berenice López Hernández

Research output: Contribution to journalArticle

Abstract

Duchenne muscular dystrophy (DMD) is a genetic neuromuscular disorder characterized by progressive weakness leading to disability. Steroid administration and physiotherapy are the most useful medical interventions in ambulant patients; In DMD, muscles present a significant deficiency of L-carnitine compared to normal subjects. Nutritional supplements are used to support management. We evaluated the effect of L-carnitine supplementation in patients that were not under steroid treatment. A double blind, controlled trial was performed in 20 patients assigned to L-carnitine or placebo treatment for one year, dose of (50 mg/kg) twice daily. Evaluations were performed every 4 months and results were analyzed using ANOVA. Variables such as age, weight, and disease onset were similar in both groups. L-carnitine supplementation was well tolerated; no significant side effects were reported during and after treatment. Clinical evaluations showed no differences between groups (p>0.05). L-carnitine supplementation does not significantly improve the function of upper and lower extremities of DMD steroid-naïve patients. Copyright © 2013 by New Century Health Publishers, LLC.
Original languageAmerican English
Pages (from-to)97-101
Number of pages86
JournalCurrent Topics in Nutraceutical Research
StatePublished - 1 Aug 2013

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Duchenne Muscular Dystrophy
Carnitine
Steroids
Inborn Genetic Diseases
Lower Extremity
Analysis of Variance
Therapeutics
Placebos
Weights and Measures
Muscles

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Escobar-Cedillo, R. E., Tintos-Hernández, J. A., Martińez-Castro, G., De Oca-Sańchez, B. M., Rodriǵuez-Jurado, R., Miranda-Duarte, A., ... López Hernández, L. B. (2013). L-carnitine supplementation in duchenne muscular dystrophy steroid-naïve patients: A pilot study. Current Topics in Nutraceutical Research, 97-101.
Escobar-Cedillo, Rosa E. ; Tintos-Hernández, Jesús A. ; Martińez-Castro, Guadalupe ; De Oca-Sańchez, Beatriz Montes ; Rodriǵuez-Jurado, Rodolfo ; Miranda-Duarte, Antonio ; Lona-Pimentel, Socorro ; Gómez-D́iaz, Benjamín ; Coral-Vázquez, Ramón M. ; Garciá, Silvia ; López Hernández, Luz Berenice. / L-carnitine supplementation in duchenne muscular dystrophy steroid-naïve patients: A pilot study. In: Current Topics in Nutraceutical Research. 2013 ; pp. 97-101.
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Escobar-Cedillo, RE, Tintos-Hernández, JA, Martińez-Castro, G, De Oca-Sańchez, BM, Rodriǵuez-Jurado, R, Miranda-Duarte, A, Lona-Pimentel, S, Gómez-D́iaz, B, Coral-Vázquez, RM, Garciá, S & López Hernández, LB 2013, 'L-carnitine supplementation in duchenne muscular dystrophy steroid-naïve patients: A pilot study', Current Topics in Nutraceutical Research, pp. 97-101.

L-carnitine supplementation in duchenne muscular dystrophy steroid-naïve patients: A pilot study. / Escobar-Cedillo, Rosa E.; Tintos-Hernández, Jesús A.; Martińez-Castro, Guadalupe; De Oca-Sańchez, Beatriz Montes; Rodriǵuez-Jurado, Rodolfo; Miranda-Duarte, Antonio; Lona-Pimentel, Socorro; Gómez-D́iaz, Benjamín; Coral-Vázquez, Ramón M.; Garciá, Silvia; López Hernández, Luz Berenice.

In: Current Topics in Nutraceutical Research, 01.08.2013, p. 97-101.

Research output: Contribution to journalArticle

TY - JOUR

T1 - L-carnitine supplementation in duchenne muscular dystrophy steroid-naïve patients: A pilot study

AU - Escobar-Cedillo, Rosa E.

AU - Tintos-Hernández, Jesús A.

AU - Martińez-Castro, Guadalupe

AU - De Oca-Sańchez, Beatriz Montes

AU - Rodriǵuez-Jurado, Rodolfo

AU - Miranda-Duarte, Antonio

AU - Lona-Pimentel, Socorro

AU - Gómez-D́iaz, Benjamín

AU - Coral-Vázquez, Ramón M.

AU - Garciá, Silvia

AU - López Hernández, Luz Berenice

PY - 2013/8/1

Y1 - 2013/8/1

N2 - Duchenne muscular dystrophy (DMD) is a genetic neuromuscular disorder characterized by progressive weakness leading to disability. Steroid administration and physiotherapy are the most useful medical interventions in ambulant patients; In DMD, muscles present a significant deficiency of L-carnitine compared to normal subjects. Nutritional supplements are used to support management. We evaluated the effect of L-carnitine supplementation in patients that were not under steroid treatment. A double blind, controlled trial was performed in 20 patients assigned to L-carnitine or placebo treatment for one year, dose of (50 mg/kg) twice daily. Evaluations were performed every 4 months and results were analyzed using ANOVA. Variables such as age, weight, and disease onset were similar in both groups. L-carnitine supplementation was well tolerated; no significant side effects were reported during and after treatment. Clinical evaluations showed no differences between groups (p>0.05). L-carnitine supplementation does not significantly improve the function of upper and lower extremities of DMD steroid-naïve patients. Copyright © 2013 by New Century Health Publishers, LLC.

AB - Duchenne muscular dystrophy (DMD) is a genetic neuromuscular disorder characterized by progressive weakness leading to disability. Steroid administration and physiotherapy are the most useful medical interventions in ambulant patients; In DMD, muscles present a significant deficiency of L-carnitine compared to normal subjects. Nutritional supplements are used to support management. We evaluated the effect of L-carnitine supplementation in patients that were not under steroid treatment. A double blind, controlled trial was performed in 20 patients assigned to L-carnitine or placebo treatment for one year, dose of (50 mg/kg) twice daily. Evaluations were performed every 4 months and results were analyzed using ANOVA. Variables such as age, weight, and disease onset were similar in both groups. L-carnitine supplementation was well tolerated; no significant side effects were reported during and after treatment. Clinical evaluations showed no differences between groups (p>0.05). L-carnitine supplementation does not significantly improve the function of upper and lower extremities of DMD steroid-naïve patients. Copyright © 2013 by New Century Health Publishers, LLC.

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Escobar-Cedillo RE, Tintos-Hernández JA, Martińez-Castro G, De Oca-Sańchez BM, Rodriǵuez-Jurado R, Miranda-Duarte A et al. L-carnitine supplementation in duchenne muscular dystrophy steroid-naïve patients: A pilot study. Current Topics in Nutraceutical Research. 2013 Aug 1;97-101.