L-alanyl-L-glutamine-supplemented parenteral nutrition decreases infectious morbidity rate in patients with severe acute pancreatitis

Clotilde Fuentes-Orozco, Gabino Cervantes-Guevara, Ivette Muciño-Hernández, Alejandro López-Ortega, Gabriela Ambriz-González, José Luis Gutiérrez-De-La-Rosa, Efraín Gómez-Herrera, José Manuel Hermosillo-Sandoval, Alejandro González-Ojeda

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Abstract

Background: The effect of parenteral GLN on recovery from severe acute pancreatitis has not been thoroughly investigated. The aims of this study were to determine whether parenteral GLN improves nutrition status and immune function, and to determine its ability to reduce morbidity and mortality in patients with this condition. Methods: In a randomized clinical trial, 44 patients with severe acute pancreatitis were randomly assigned to receive either standard PN (n = 22) or L-alanyl-L-glutamine-supplemented PN (n = 22) after hospital admission. Nitrogen balance, counts of leukocytes, total lymphocytes, and CD4 and CD8 subpopulations, and serum levels of immunoglobulin A, total protein, albumin, C-reactive protein, and serum interleukin (IL)-6 and IL-10 were measured on days 0, 5, and 10. Hospital stay, infectious morbidity, and mortality were also evaluated. Results: Demographics, laboratory characteristics, and pancreatitis etiology and severity at entry to the study were similar between groups. The study group exhibited significant increases in serum IL-10 levels, total lymphocyte and lymphocyte subpopulation counts, and albumin serum levels. Nitrogen balance also improved to positive levels in the study group and remained negative in the control group. Infectious morbidity was more frequent in the control group than in the study group. The duration of hospital stay was similar between groups, as was mortality. Conclusion: The results suggest that treatment of patients with GLN-supplemented PN may decrease infectious morbidity rate compared with those who treated with nonenriched PN. © 2008 American Society for Parenteral and Enteral Nutrition.
Original languageAmerican English
Pages (from-to)403-411
Number of pages9
JournalJournal of Parenteral and Enteral Nutrition
DOIs
StatePublished - 1 Jul 2008
Externally publishedYes

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alanylglutamine
Parenteral Nutrition
Glutamine
Pancreatitis
Morbidity
Lymphocyte Count
Interleukin-10
Mortality
Length of Stay
Nitrogen
Serum
Control Groups
Lymphocyte Subsets
Protein C
Nutritional Status
Serum Albumin
C-Reactive Protein
Immunoglobulin A
Albumins
Interleukin-6

Cite this

Fuentes-Orozco, C., Cervantes-Guevara, G., Muciño-Hernández, I., López-Ortega, A., Ambriz-González, G., Gutiérrez-De-La-Rosa, J. L., ... González-Ojeda, A. (2008). L-alanyl-L-glutamine-supplemented parenteral nutrition decreases infectious morbidity rate in patients with severe acute pancreatitis. Journal of Parenteral and Enteral Nutrition, 403-411. https://doi.org/10.1177/0148607108319797
Fuentes-Orozco, Clotilde ; Cervantes-Guevara, Gabino ; Muciño-Hernández, Ivette ; López-Ortega, Alejandro ; Ambriz-González, Gabriela ; Gutiérrez-De-La-Rosa, José Luis ; Gómez-Herrera, Efraín ; Hermosillo-Sandoval, José Manuel ; González-Ojeda, Alejandro. / L-alanyl-L-glutamine-supplemented parenteral nutrition decreases infectious morbidity rate in patients with severe acute pancreatitis. In: Journal of Parenteral and Enteral Nutrition. 2008 ; pp. 403-411.
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abstract = "Background: The effect of parenteral GLN on recovery from severe acute pancreatitis has not been thoroughly investigated. The aims of this study were to determine whether parenteral GLN improves nutrition status and immune function, and to determine its ability to reduce morbidity and mortality in patients with this condition. Methods: In a randomized clinical trial, 44 patients with severe acute pancreatitis were randomly assigned to receive either standard PN (n = 22) or L-alanyl-L-glutamine-supplemented PN (n = 22) after hospital admission. Nitrogen balance, counts of leukocytes, total lymphocytes, and CD4 and CD8 subpopulations, and serum levels of immunoglobulin A, total protein, albumin, C-reactive protein, and serum interleukin (IL)-6 and IL-10 were measured on days 0, 5, and 10. Hospital stay, infectious morbidity, and mortality were also evaluated. Results: Demographics, laboratory characteristics, and pancreatitis etiology and severity at entry to the study were similar between groups. The study group exhibited significant increases in serum IL-10 levels, total lymphocyte and lymphocyte subpopulation counts, and albumin serum levels. Nitrogen balance also improved to positive levels in the study group and remained negative in the control group. Infectious morbidity was more frequent in the control group than in the study group. The duration of hospital stay was similar between groups, as was mortality. Conclusion: The results suggest that treatment of patients with GLN-supplemented PN may decrease infectious morbidity rate compared with those who treated with nonenriched PN. {\circledC} 2008 American Society for Parenteral and Enteral Nutrition.",
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Fuentes-Orozco, C, Cervantes-Guevara, G, Muciño-Hernández, I, López-Ortega, A, Ambriz-González, G, Gutiérrez-De-La-Rosa, JL, Gómez-Herrera, E, Hermosillo-Sandoval, JM & González-Ojeda, A 2008, 'L-alanyl-L-glutamine-supplemented parenteral nutrition decreases infectious morbidity rate in patients with severe acute pancreatitis', Journal of Parenteral and Enteral Nutrition, pp. 403-411. https://doi.org/10.1177/0148607108319797

L-alanyl-L-glutamine-supplemented parenteral nutrition decreases infectious morbidity rate in patients with severe acute pancreatitis. / Fuentes-Orozco, Clotilde; Cervantes-Guevara, Gabino; Muciño-Hernández, Ivette; López-Ortega, Alejandro; Ambriz-González, Gabriela; Gutiérrez-De-La-Rosa, José Luis; Gómez-Herrera, Efraín; Hermosillo-Sandoval, José Manuel; González-Ojeda, Alejandro.

In: Journal of Parenteral and Enteral Nutrition, 01.07.2008, p. 403-411.

Research output: Contribution to journalArticle

TY - JOUR

T1 - L-alanyl-L-glutamine-supplemented parenteral nutrition decreases infectious morbidity rate in patients with severe acute pancreatitis

AU - Fuentes-Orozco, Clotilde

AU - Cervantes-Guevara, Gabino

AU - Muciño-Hernández, Ivette

AU - López-Ortega, Alejandro

AU - Ambriz-González, Gabriela

AU - Gutiérrez-De-La-Rosa, José Luis

AU - Gómez-Herrera, Efraín

AU - Hermosillo-Sandoval, José Manuel

AU - González-Ojeda, Alejandro

PY - 2008/7/1

Y1 - 2008/7/1

N2 - Background: The effect of parenteral GLN on recovery from severe acute pancreatitis has not been thoroughly investigated. The aims of this study were to determine whether parenteral GLN improves nutrition status and immune function, and to determine its ability to reduce morbidity and mortality in patients with this condition. Methods: In a randomized clinical trial, 44 patients with severe acute pancreatitis were randomly assigned to receive either standard PN (n = 22) or L-alanyl-L-glutamine-supplemented PN (n = 22) after hospital admission. Nitrogen balance, counts of leukocytes, total lymphocytes, and CD4 and CD8 subpopulations, and serum levels of immunoglobulin A, total protein, albumin, C-reactive protein, and serum interleukin (IL)-6 and IL-10 were measured on days 0, 5, and 10. Hospital stay, infectious morbidity, and mortality were also evaluated. Results: Demographics, laboratory characteristics, and pancreatitis etiology and severity at entry to the study were similar between groups. The study group exhibited significant increases in serum IL-10 levels, total lymphocyte and lymphocyte subpopulation counts, and albumin serum levels. Nitrogen balance also improved to positive levels in the study group and remained negative in the control group. Infectious morbidity was more frequent in the control group than in the study group. The duration of hospital stay was similar between groups, as was mortality. Conclusion: The results suggest that treatment of patients with GLN-supplemented PN may decrease infectious morbidity rate compared with those who treated with nonenriched PN. © 2008 American Society for Parenteral and Enteral Nutrition.

AB - Background: The effect of parenteral GLN on recovery from severe acute pancreatitis has not been thoroughly investigated. The aims of this study were to determine whether parenteral GLN improves nutrition status and immune function, and to determine its ability to reduce morbidity and mortality in patients with this condition. Methods: In a randomized clinical trial, 44 patients with severe acute pancreatitis were randomly assigned to receive either standard PN (n = 22) or L-alanyl-L-glutamine-supplemented PN (n = 22) after hospital admission. Nitrogen balance, counts of leukocytes, total lymphocytes, and CD4 and CD8 subpopulations, and serum levels of immunoglobulin A, total protein, albumin, C-reactive protein, and serum interleukin (IL)-6 and IL-10 were measured on days 0, 5, and 10. Hospital stay, infectious morbidity, and mortality were also evaluated. Results: Demographics, laboratory characteristics, and pancreatitis etiology and severity at entry to the study were similar between groups. The study group exhibited significant increases in serum IL-10 levels, total lymphocyte and lymphocyte subpopulation counts, and albumin serum levels. Nitrogen balance also improved to positive levels in the study group and remained negative in the control group. Infectious morbidity was more frequent in the control group than in the study group. The duration of hospital stay was similar between groups, as was mortality. Conclusion: The results suggest that treatment of patients with GLN-supplemented PN may decrease infectious morbidity rate compared with those who treated with nonenriched PN. © 2008 American Society for Parenteral and Enteral Nutrition.

U2 - 10.1177/0148607108319797

DO - 10.1177/0148607108319797

M3 - Article

C2 - 18596311

SP - 403

EP - 411

JO - Journal of Parenteral and Enteral Nutrition

JF - Journal of Parenteral and Enteral Nutrition

SN - 0148-6071

ER -