TY - JOUR
T1 - Is there any correlation between alpha-synuclein levels in tears and retinal layer thickness in Parkinson's disease?
AU - Camacho-Ordonez, Azyadeh
AU - Cervantes-Arriaga, Amin
AU - Rodríguez-Violante, Mayela
AU - Hernandez-Medrano, Ana Jimena
AU - Somilleda-Ventura, Selma Alin
AU - Pérez-Cano, Hector J.
AU - Nava-Castañeda, Ángel
AU - Guerrero-Berger, Oscar
N1 - Publisher Copyright:
© The Author(s) 2023.
PY - 2024/1
Y1 - 2024/1
N2 - Purpose: To determine the total alpha-synuclein (αSyn) reflex tears and its association with retinal layers thickness in Parkinson's disease (PD). Methods: Fifty-two eyes of 26 PD subjects and 52 eyes of age-and sex-matched healthy controls were included. Total αSyn in reflex tears was quantified using a human total αSyn enzyme-linked immunosorbent assay (ELISA) kit. The retinal thickness was evaluated with spectral-domain optical coherence tomography. The Movement Disorder Society-Unified Parkinsońs Disease Rating Scale (MDS-UPDRS), Non-Motor Symptoms Scale (NMSS), and Montreal Cognitive Assessment (MoCA) were used to assess motor, non-motor, and cognition. Results: In PD, total αSyn levels were increased compared to control subjects [1.76pg/mL (IQR 1.74–1.80) vs 1.73pg/mL (IQR 1.70–1.77), p < 0.004]. The nerve fiber layer, ganglion cell layer, internal plexiform layer, inner nuclear layer, and outer nuclear layer were thinner in PD in comparison with controls (p < 0.05). The outer plexiform layer and retinal pigment epithelium were thicker in PD (p < 0.05). The total αSyn levels positively correlated with the central volume of the inner nuclear layer (r = 0.357, p = 0.009). Conclusion: Total αSyn reflex tear levels were increased in subjects with PD compared to controls. PD patients showed significant thinning of the inner retinal layers and thickening of outer retinal layers in comparison with controls. Total αSyn levels positively correlate with the central volume of the inner nuclear layer in PD. The combination of these biomarkers might have a possible role as a diagnostic tool in PD subjects.
AB - Purpose: To determine the total alpha-synuclein (αSyn) reflex tears and its association with retinal layers thickness in Parkinson's disease (PD). Methods: Fifty-two eyes of 26 PD subjects and 52 eyes of age-and sex-matched healthy controls were included. Total αSyn in reflex tears was quantified using a human total αSyn enzyme-linked immunosorbent assay (ELISA) kit. The retinal thickness was evaluated with spectral-domain optical coherence tomography. The Movement Disorder Society-Unified Parkinsońs Disease Rating Scale (MDS-UPDRS), Non-Motor Symptoms Scale (NMSS), and Montreal Cognitive Assessment (MoCA) were used to assess motor, non-motor, and cognition. Results: In PD, total αSyn levels were increased compared to control subjects [1.76pg/mL (IQR 1.74–1.80) vs 1.73pg/mL (IQR 1.70–1.77), p < 0.004]. The nerve fiber layer, ganglion cell layer, internal plexiform layer, inner nuclear layer, and outer nuclear layer were thinner in PD in comparison with controls (p < 0.05). The outer plexiform layer and retinal pigment epithelium were thicker in PD (p < 0.05). The total αSyn levels positively correlated with the central volume of the inner nuclear layer (r = 0.357, p = 0.009). Conclusion: Total αSyn reflex tear levels were increased in subjects with PD compared to controls. PD patients showed significant thinning of the inner retinal layers and thickening of outer retinal layers in comparison with controls. Total αSyn levels positively correlate with the central volume of the inner nuclear layer in PD. The combination of these biomarkers might have a possible role as a diagnostic tool in PD subjects.
KW - Parkinson's disease
KW - Total alpha-synuclein
KW - optical coherence tomography
KW - reflex tears
KW - retinal layers
UR - http://www.scopus.com/inward/record.url?scp=85158824400&partnerID=8YFLogxK
U2 - 10.1177/11206721231173725
DO - 10.1177/11206721231173725
M3 - Artículo
C2 - 37151018
AN - SCOPUS:85158824400
SN - 1120-6721
VL - 34
SP - 252
EP - 259
JO - European Journal of Ophthalmology
JF - European Journal of Ophthalmology
IS - 1
ER -