TY - JOUR
T1 - Insertions of antihypertensive peptides and their applications in pharmacy and functional foods
AU - Morales-Camacho, Jocksan I.
AU - Espinosa-Hernández, Edgar
AU - Rosas-Cárdenas, F. Fátima
AU - Semería-Maitret, Tamara
AU - Luna-Suárez, Silvia
N1 - Publisher Copyright:
© 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2019/3/15
Y1 - 2019/3/15
N2 - Hypertension is a worldwide health problem. It is the main cardiovascular risk factor and affects about 31% of the world’s adult population. The drugs used to control hypertension may cause side effects; for this reason, there are many investigations focused on searching for alternatives to control or prevent this disease through diet. For example, many peptides have demonstrated antihypertensive effects. The insertion of bioactive peptides is a biotechnological implement used to improve the nutraceutical properties of proteins. This work reviews the current data on the insertion of antihypertensive peptides (AHPs) into food proteins, the systems used to produce the AHPs, the advantages and disadvantages between them, the parameters to produce them at major scales, and their potential applications in pharmacy and functional foods.
AB - Hypertension is a worldwide health problem. It is the main cardiovascular risk factor and affects about 31% of the world’s adult population. The drugs used to control hypertension may cause side effects; for this reason, there are many investigations focused on searching for alternatives to control or prevent this disease through diet. For example, many peptides have demonstrated antihypertensive effects. The insertion of bioactive peptides is a biotechnological implement used to improve the nutraceutical properties of proteins. This work reviews the current data on the insertion of antihypertensive peptides (AHPs) into food proteins, the systems used to produce the AHPs, the advantages and disadvantages between them, the parameters to produce them at major scales, and their potential applications in pharmacy and functional foods.
KW - Antihypertensive peptides
KW - Functional foods
KW - Fusion protein
KW - Modified protein
KW - Protein engineering
KW - Protein expression
UR - http://www.scopus.com/inward/record.url?scp=85060816540&partnerID=8YFLogxK
U2 - 10.1007/s00253-019-09633-1
DO - 10.1007/s00253-019-09633-1
M3 - Artículo de revisión
C2 - 30693404
SN - 0175-7598
VL - 103
SP - 2493
EP - 2505
JO - Applied Microbiology and Biotechnology
JF - Applied Microbiology and Biotechnology
IS - 6
ER -