Insertions of antihypertensive peptides and their applications in pharmacy and functional foods

Jocksan I. Morales-Camacho, Edgar Espinosa-Hernández, F. Fátima Rosas-Cárdenas, Tamara Semería-Maitret, Silvia Luna-Suárez

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Hypertension is a worldwide health problem. It is the main cardiovascular risk factor and affects about 31% of the world’s adult population. The drugs used to control hypertension may cause side effects; for this reason, there are many investigations focused on searching for alternatives to control or prevent this disease through diet. For example, many peptides have demonstrated antihypertensive effects. The insertion of bioactive peptides is a biotechnological implement used to improve the nutraceutical properties of proteins. This work reviews the current data on the insertion of antihypertensive peptides (AHPs) into food proteins, the systems used to produce the AHPs, the advantages and disadvantages between them, the parameters to produce them at major scales, and their potential applications in pharmacy and functional foods.

Original languageEnglish
Pages (from-to)2493-2505
Number of pages13
JournalApplied Microbiology and Biotechnology
Volume103
Issue number6
DOIs
StatePublished - 15 Mar 2019

Keywords

  • Antihypertensive peptides
  • Functional foods
  • Fusion protein
  • Modified protein
  • Protein engineering
  • Protein expression

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