Inotropic activity induced by carbamazepine-alkyne derivative in an isolated heart model and perfused to constant flow

Lauro Figueroa-Valverde, Francisco Díaz-Cedillo, María López-Ramos, Elodia García-Cervera, Karen Quijano-Ascencio

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Introduction: Few data exist with respect to the effects of carbamazepine and its derivatives at cardiovascular level; furthermore, the molecular mechanisms and cellular site of action are still unclear. Objective: The effects induced by carbamazepine-alquine derivative on perfusion pressure, vascular resistance and left ventricular pressure were evaluated. Materials and methods: The effects of carbamazepine and carbamazepine-alquine on the perfusion pressure, vascular resistance and left ventricular pressure were examined in isolated rat hearts (Langendorff model). Results: Four results were obtained: (1) The carbamazepine-alquine derivative [10-9mM] increased the perfusion pressure and vascular resistance in comparison with the carbamazepine [10-9mM]; (2) the effect of carbamazepine-alquine derivative [10-9-10-4mM] on left ventricular pressure not was inhibited by metoprolol or prazosin at a dose of 10-6 mM; (3) nifedipine [10-6mM] blocked the effects exerted by the carbamazepine-alquine derivative [10-9-10-4mM] on left ventricular pressure, and (4) the carbamazepine-alquine derivative at dose of 10-9mM increased the concentration of intracellular calcium over a time period of 3-18 min; nevertheless, in presence of nifedipine [10-6mM] this effect was inhibited significantly (p=0.005). Conclusions: The activity exerted by carbamazepine-alquine derivative on perfusion pressure, vascular resistance and left ventricular pressure involved activation of calcium channel type-L, brought indirectly changes in the intracellular calcium levels and subsequently induced a positive inotropic effect.
Original languageAmerican English
Pages (from-to)232-241
Number of pages207
JournalBiomedica
StatePublished - 1 Apr 2011

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Alkynes
Carbamazepine
Derivatives
Ventricular Pressure
Vascular Resistance
Perfusion
Pressure
Isolated Heart Preparation
Calcium
L-Type Calcium Channels
Metoprolol
Prazosin
Nifedipine
Rats
Chemical activation

Cite this

Figueroa-Valverde, L., Díaz-Cedillo, F., López-Ramos, M., García-Cervera, E., & Quijano-Ascencio, K. (2011). Inotropic activity induced by carbamazepine-alkyne derivative in an isolated heart model and perfused to constant flow. Biomedica, 232-241.
Figueroa-Valverde, Lauro ; Díaz-Cedillo, Francisco ; López-Ramos, María ; García-Cervera, Elodia ; Quijano-Ascencio, Karen. / Inotropic activity induced by carbamazepine-alkyne derivative in an isolated heart model and perfused to constant flow. In: Biomedica. 2011 ; pp. 232-241.
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Figueroa-Valverde, L, Díaz-Cedillo, F, López-Ramos, M, García-Cervera, E & Quijano-Ascencio, K 2011, 'Inotropic activity induced by carbamazepine-alkyne derivative in an isolated heart model and perfused to constant flow', Biomedica, pp. 232-241.

Inotropic activity induced by carbamazepine-alkyne derivative in an isolated heart model and perfused to constant flow. / Figueroa-Valverde, Lauro; Díaz-Cedillo, Francisco; López-Ramos, María; García-Cervera, Elodia; Quijano-Ascencio, Karen.

In: Biomedica, 01.04.2011, p. 232-241.

Research output: Contribution to journalArticle

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T1 - Inotropic activity induced by carbamazepine-alkyne derivative in an isolated heart model and perfused to constant flow

AU - Figueroa-Valverde, Lauro

AU - Díaz-Cedillo, Francisco

AU - López-Ramos, María

AU - García-Cervera, Elodia

AU - Quijano-Ascencio, Karen

PY - 2011/4/1

Y1 - 2011/4/1

N2 - Introduction: Few data exist with respect to the effects of carbamazepine and its derivatives at cardiovascular level; furthermore, the molecular mechanisms and cellular site of action are still unclear. Objective: The effects induced by carbamazepine-alquine derivative on perfusion pressure, vascular resistance and left ventricular pressure were evaluated. Materials and methods: The effects of carbamazepine and carbamazepine-alquine on the perfusion pressure, vascular resistance and left ventricular pressure were examined in isolated rat hearts (Langendorff model). Results: Four results were obtained: (1) The carbamazepine-alquine derivative [10-9mM] increased the perfusion pressure and vascular resistance in comparison with the carbamazepine [10-9mM]; (2) the effect of carbamazepine-alquine derivative [10-9-10-4mM] on left ventricular pressure not was inhibited by metoprolol or prazosin at a dose of 10-6 mM; (3) nifedipine [10-6mM] blocked the effects exerted by the carbamazepine-alquine derivative [10-9-10-4mM] on left ventricular pressure, and (4) the carbamazepine-alquine derivative at dose of 10-9mM increased the concentration of intracellular calcium over a time period of 3-18 min; nevertheless, in presence of nifedipine [10-6mM] this effect was inhibited significantly (p=0.005). Conclusions: The activity exerted by carbamazepine-alquine derivative on perfusion pressure, vascular resistance and left ventricular pressure involved activation of calcium channel type-L, brought indirectly changes in the intracellular calcium levels and subsequently induced a positive inotropic effect.

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Figueroa-Valverde L, Díaz-Cedillo F, López-Ramos M, García-Cervera E, Quijano-Ascencio K. Inotropic activity induced by carbamazepine-alkyne derivative in an isolated heart model and perfused to constant flow. Biomedica. 2011 Apr 1;232-241.