Inhibitory effect of buspirone and diazepam, but not of 8-OH-DPAT, on maternal behavior and aggression

A. Ferreira, O. Picazo, N. Uriarte, M. Pereira, A. Fernández-Guasti

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The action of diazepam (0.0, 1.0, and 2.0 mg/kg) and the serotonergic compounds buspirone (0.0, 2.5, and 5.0 mg/kg) and 8-OH-DPAT (0.0, 0.1, and 1.0 mg/kg) on maternal behavior and aggression were studied. An activity test was made after these treatments to control for unspecific actions due to motor impairment. Diazepam and buspirone dose-dependently inhibited the expression of maternal aggression and the active components of maternal behavior such as retrieving and nest building. 8-OH-DPAT did not affect these behaviors. 8-OH-DPAT (1.0 mg/kg) provoked the serotonergic syndrome and hypothermia; however, ovariectomized animals showed more signs of the syndrome and a decrease in body temperature after 8-OH-DPAT than lactating rats. Buspirone, but not the other anxiolytics, reduced motor activity. The role of drugs acting at the serotonergic, dopaminergic, and GABA-benzodiazepine systems in the control of maternal behavior and aggression is discussed. Copyright (C) 2000 Elsevier Science Inc.
Original languageAmerican English
Pages (from-to)389-396
Number of pages349
JournalPharmacology Biochemistry and Behavior
DOIs
StatePublished - 1 Jun 2000

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Buspirone
Maternal Behavior
8-Hydroxy-2-(di-n-propylamino)tetralin
Diazepam
Aggression
hypothermia
Hypothermia
body temperature
Anti-Anxiety Agents
impairment
Body Temperature
Benzodiazepines
gamma-Aminobutyric Acid
rats
animals
Rats
Animals
Motor Activity
drugs
Mothers

Cite this

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title = "Inhibitory effect of buspirone and diazepam, but not of 8-OH-DPAT, on maternal behavior and aggression",
abstract = "The action of diazepam (0.0, 1.0, and 2.0 mg/kg) and the serotonergic compounds buspirone (0.0, 2.5, and 5.0 mg/kg) and 8-OH-DPAT (0.0, 0.1, and 1.0 mg/kg) on maternal behavior and aggression were studied. An activity test was made after these treatments to control for unspecific actions due to motor impairment. Diazepam and buspirone dose-dependently inhibited the expression of maternal aggression and the active components of maternal behavior such as retrieving and nest building. 8-OH-DPAT did not affect these behaviors. 8-OH-DPAT (1.0 mg/kg) provoked the serotonergic syndrome and hypothermia; however, ovariectomized animals showed more signs of the syndrome and a decrease in body temperature after 8-OH-DPAT than lactating rats. Buspirone, but not the other anxiolytics, reduced motor activity. The role of drugs acting at the serotonergic, dopaminergic, and GABA-benzodiazepine systems in the control of maternal behavior and aggression is discussed. Copyright (C) 2000 Elsevier Science Inc.",
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Inhibitory effect of buspirone and diazepam, but not of 8-OH-DPAT, on maternal behavior and aggression. / Ferreira, A.; Picazo, O.; Uriarte, N.; Pereira, M.; Fernández-Guasti, A.

In: Pharmacology Biochemistry and Behavior, 01.06.2000, p. 389-396.

Research output: Contribution to journalArticle

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