Inhibition of squalene synthase of rat liver by abietane diterpenes derivatives

Mariana Macías-Alonso, Lucía S. Andrés, Iván Córdova-Guerrero, Arturo Estolano-Cobián, Laura Díaz-Rubio, Joaquín G. Marrero

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

In the current study, chemical composition of cultivated Salvia canariensis L was determined. Carnosol was the main product isolated. We prepared more lipophilic derivatives from carnosol, and both isolated and semisynthetic abietane diterpenes were evaluated in vitro as inhibitors of squalene synthase. Among the compounds tested, carnosol was the most potent inhibitor (IC50 = 17.6 μM). These results highlight the great potential of this species for the production of new ingredients in nutritional supplements for the treatment of hyperlipidemia.

Original languageEnglish
Pages (from-to)2972-2976
Number of pages5
JournalNatural Product Research
Volume35
Issue number17
DOIs
StatePublished - 2021

Keywords

  • Carnosol
  • Cholesterol
  • Hyperlipidemia
  • Salvia
  • Squalene synthase

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