TY - JOUR
T1 - Inhibition of squalene synthase of rat liver by abietane diterpenes derivatives
AU - Macías-Alonso, Mariana
AU - Andrés, Lucía S.
AU - Córdova-Guerrero, Iván
AU - Estolano-Cobián, Arturo
AU - Díaz-Rubio, Laura
AU - Marrero, Joaquín G.
N1 - Publisher Copyright:
© 2019 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021
Y1 - 2021
N2 - In the current study, chemical composition of cultivated Salvia canariensis L was determined. Carnosol was the main product isolated. We prepared more lipophilic derivatives from carnosol, and both isolated and semisynthetic abietane diterpenes were evaluated in vitro as inhibitors of squalene synthase. Among the compounds tested, carnosol was the most potent inhibitor (IC50 = 17.6 μM). These results highlight the great potential of this species for the production of new ingredients in nutritional supplements for the treatment of hyperlipidemia.
AB - In the current study, chemical composition of cultivated Salvia canariensis L was determined. Carnosol was the main product isolated. We prepared more lipophilic derivatives from carnosol, and both isolated and semisynthetic abietane diterpenes were evaluated in vitro as inhibitors of squalene synthase. Among the compounds tested, carnosol was the most potent inhibitor (IC50 = 17.6 μM). These results highlight the great potential of this species for the production of new ingredients in nutritional supplements for the treatment of hyperlipidemia.
KW - Carnosol
KW - Cholesterol
KW - Hyperlipidemia
KW - Salvia
KW - Squalene synthase
UR - http://www.scopus.com/inward/record.url?scp=85074486038&partnerID=8YFLogxK
U2 - 10.1080/14786419.2019.1678614
DO - 10.1080/14786419.2019.1678614
M3 - Artículo
C2 - 31631695
SN - 1478-6419
VL - 35
SP - 2972
EP - 2976
JO - Natural Product Research
JF - Natural Product Research
IS - 17
ER -