Inhibition of complement activity in murine leprosy

O. Rojas-Espinosa, A. Oltra, P. Arce, P. Mendez

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

NIH mice infected with Mycobacterium lepraemurium (MLM) show a marked depression in their levels of hemolytic complement that is proportional to the degree of infection. The defect affects more the activation of complement through the classical pathway (CPW) than the activation of complement through the alternative pathway. Although this low activity of CPW-complement may be due to different causes (complement consumption by the infecting microorganism, lack of biosynthesis of complement components, or the presence of complement inhibitory factors), our results seem to support the last possibility. The generation of factors in the infected animals that inhibit the autologous activity of complement as the infection goes on reduces the risk of complement-mediated tissue damage and prolongs the survival time of the host, a wise strategy on the part of the MLM to assure its own survival as a parasite.
Original languageAmerican English
Pages (from-to)605-612
Number of pages543
JournalInternational Journal of Leprosy
StatePublished - 1 Dec 1991

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leprosy
Classical Complement Pathway
Mycobacterium lepraemurium
Leprosy
Chemical activation
Biosynthesis
Microorganisms
Alternative Complement Pathway
defect
parasite
Animals
microorganism
Tissue
Infection
Defects
damage
animal
Complement System Proteins
Parasites
infection

Cite this

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Inhibition of complement activity in murine leprosy. / Rojas-Espinosa, O.; Oltra, A.; Arce, P.; Mendez, P.

In: International Journal of Leprosy, 01.12.1991, p. 605-612.

Research output: Contribution to journalArticle

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