Infrared irradiation-assisted multicomponent synthesis of 2-amino-3-cyano-4h-pyran derivatives

Arturo Sánchez, Fernando Hernández, Paulo César Cruz, Yolanda Alcaraz, Joaquín Tamariz, Francisco Delgado, Miguel A. Vázquez

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

A simple, versatile, and efficient synthesis of 4H-pyran derivative compounds is achieved via a three-component cyclocon-densation of aldehydes, malononitrile, and ethyl acetoacetate, using ammonium hydroxide as the catalyst, promoted by infrared irradiation. The present method offers several advantages, such as high yields, non hazardous reaction conditions as well as short reaction times.

Original languageEnglish
Pages (from-to)121-127
Number of pages7
JournalJournal of the Mexican Chemical Society
Volume56
Issue number2
StatePublished - Apr 2012

Keywords

  • 4H-pyrans
  • Infrared irradiation
  • MCR
  • Three-component reaction

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