Influence of triiodothyronine on the contractile effect of D-nor-pseudoephedrine

Carlos Castillo-Henkel, Jorge Loṕez-Canales, María Del Carmen Castillo-Hernández, Juan Asbun-Bojalil, Raul Moriń-Zaragoza, Daniel Rodríguez-Chorẽ

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Abstract

Here we contrast the vascular smooth muscle contractility produced by D-nor-pseudoephedrine, alone or combined with triiodothyronine, on the aorta and coronary vasculature of the rat. At high concentrations (greater than those found in normal therapeutic dosing) D-nor-pseudoephedrine contracted the aorta. In contrast, it produced vasodilation on pre-contracted aorta independently of the vasoconstrictor employed or the presence of vascular endothelium. D-nor-pseudoephedrine increased coronary perfusion pressure, but the effect was smaller than the vasoconstriction produced by phenylephrine (a full α 1 adrenergic agonist), and was blocked by the pre-treatment with triiodothyronine. These results suggest cardiovascular risks in the use of D-nor-pseudoephedrine for weight loss.

Original languageEnglish
Pages (from-to)33-36
Number of pages4
JournalProceedings of the Western Pharmacology Society
Volume53
StatePublished - 2010

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