TY - JOUR
T1 - In vivo antigiardial activity of three flavonoids isolated of some medicinal plants used in Mexican traditional medicine for the treatment of diarrhea
AU - Barbosa, Elizabeth
AU - Calzada, Fernando
AU - Campos, Rafael
PY - 2007/2/12
Y1 - 2007/2/12
N2 - Mexican traditional medicine uses a great variety of plants in the treatment of gastrointestinal disorders such as diarrhea. In order to understand the properties of some of their chemical constituents, three flavonoids (kaempferol, tiliroside and (-)-epicatechin) isolated from Geranium mexicanum, Cuphea pinetorum, Helianthemum glomeratum, and Rubus coriifolius, were assayed to demonstrate their in vivo antiprotozoal activity; using an experimental infection of Giardia lamblia in suckling female CD-1 mice. Compounds tested showed antigiardial activity with values of ED50 (μmol/kg) 0.072 for (-)-epicatechin, 2.057 for kaempferol and 1.429 for tiliroside. The most active flavonoid was the (-)-epicatechin, its activity was higher than metronidazole and emetine, drugs used as positive controls. In the case of kaempferol and tiliroside their potency was close to that of the metronidazole, but far less than emetine.
AB - Mexican traditional medicine uses a great variety of plants in the treatment of gastrointestinal disorders such as diarrhea. In order to understand the properties of some of their chemical constituents, three flavonoids (kaempferol, tiliroside and (-)-epicatechin) isolated from Geranium mexicanum, Cuphea pinetorum, Helianthemum glomeratum, and Rubus coriifolius, were assayed to demonstrate their in vivo antiprotozoal activity; using an experimental infection of Giardia lamblia in suckling female CD-1 mice. Compounds tested showed antigiardial activity with values of ED50 (μmol/kg) 0.072 for (-)-epicatechin, 2.057 for kaempferol and 1.429 for tiliroside. The most active flavonoid was the (-)-epicatechin, its activity was higher than metronidazole and emetine, drugs used as positive controls. In the case of kaempferol and tiliroside their potency was close to that of the metronidazole, but far less than emetine.
KW - (-)-Epicatechin
KW - Antigiardial activity
KW - Flavonoids
KW - Giardia lamblia
KW - Kaempferol
KW - Medicinal plants
KW - Tiliroside
UR - http://www.scopus.com/inward/record.url?scp=33846162296&partnerID=8YFLogxK
U2 - 10.1016/j.jep.2006.09.009
DO - 10.1016/j.jep.2006.09.009
M3 - Artículo
C2 - 17052875
SN - 0378-8741
VL - 109
SP - 552
EP - 554
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
IS - 3
ER -