TY - JOUR
T1 - In vitro apoptotic activity of 2,2-diphenyl-1,3,2-oxazaborolidin-5-ones in L5178Y cells
AU - Velasco, Benjamín
AU - Trujillo-Ferrara, José G.
AU - Castillo, Luis H.Fabila
AU - Miranda, René
AU - Sánchez-Torres, Luvia E.
N1 - Funding Information:
This research was financially supported by SIP grants 20040289 and 20050322. Benjamín Velasco thanks CONACyT for a scholarship; and Cátedra IN1-71 FESC-UNAM, for financial support. Luvia Enid Sánchez-Torres, José G. Trujillo-Ferrara and Luis Fabila Castillo are fellows of COFAA-IPN, EDI-IPN.
PY - 2007/2/2
Y1 - 2007/2/2
N2 - Compounds containing B-N bonds have shown interesting biological activity. One class of such molecules is the 2,2-diphenyl-1,3,2-oxazaborolidin-5-ones (3a-j), which contain a B-N bond, have an α-amino acid moiety in the heterocycle, and have an exocyclic moiety related to an amino acid. The purpose of this work was to determine the inhibitory effects of 3a-j on the proliferation of murine L5178Y lymphoma cells. A new five-membered heterocyclic nucleus with apoptotic activity was found. The target products showed potent cytotoxicity in the L5178Y cell line. Among them, 3a exhibited the highest antineoplastic activity in L5178Y cells with an IC50 value of 22.5 ± 0.2 μM.
AB - Compounds containing B-N bonds have shown interesting biological activity. One class of such molecules is the 2,2-diphenyl-1,3,2-oxazaborolidin-5-ones (3a-j), which contain a B-N bond, have an α-amino acid moiety in the heterocycle, and have an exocyclic moiety related to an amino acid. The purpose of this work was to determine the inhibitory effects of 3a-j on the proliferation of murine L5178Y lymphoma cells. A new five-membered heterocyclic nucleus with apoptotic activity was found. The target products showed potent cytotoxicity in the L5178Y cell line. Among them, 3a exhibited the highest antineoplastic activity in L5178Y cells with an IC50 value of 22.5 ± 0.2 μM.
KW - Antineoplastic
KW - Apoptosis
KW - Cytotoxicity
KW - Diphenyloxazaborolidinones
KW - L5178Y cell
UR - http://www.scopus.com/inward/record.url?scp=33846817385&partnerID=8YFLogxK
U2 - 10.1016/j.lfs.2006.11.034
DO - 10.1016/j.lfs.2006.11.034
M3 - Artículo
C2 - 17208255
SN - 0024-3205
VL - 80
SP - 1007
EP - 1013
JO - Life Sciences
JF - Life Sciences
IS - 11
ER -