In vitro and in vivo assessment of newer quinoxaline–oxadiazole hybrids as antimicrobial and antiprotozoal agents

Navin B. Patel; Jignesh N. Patel; Amit C. Purohit; Vatsal M. Patel; Dhanji P. Rajani; Rosa Moo-Puc; Julio Cesar Lopez-Cedillo; Benjamin Nogueda-Torres; Gildardo Rivera

doi:10.1016/j.ijantimicag.2017.04.016

In vitro and in vivo assessment of newer quinoxaline–oxadiazole hybrids as antimicrobial and antiprotozoal agents

Navin B. Patel, Jignesh N. Patel, Amit C. Purohit, Vatsal M. Patel, Dhanji P. Rajani, Rosa Moo-Puc, Julio Cesar Lopez-Cedillo, Benjamin Nogueda-Torres, Gildardo Rivera

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

A new series of N-(substituted-phenyl)-2-[5-(quinoxalin-2-yloxymethyl)-[1,3,4] oxadiazol-2-ylsulfanyl]-acetamides (5a–o) was designed and synthesised from the parent compound 2-hydroxy quinoxaline (1) through a multistep reaction sequence and was characterised by spectral and elemental analyses. All of the compounds synthesised were evaluated for their antimicrobial and antiprotozoal activities. The results revealed that quinoxaline-based 1,3,4-oxadiazoles displayed promising antibacterial, antifungal and anti-Trypanosoma cruzi activities compared with reference drugs, particularly the lead compound 5l in a short-term in vivo model in T. cruzi.

Original language	English
Pages (from-to)	413-418
Number of pages	6
Journal	International Journal of Antimicrobial Agents
Volume	50
Issue number	3
DOIs	https://doi.org/10.1016/j.ijantimicag.2017.04.016
State	Published - Sep 2017

Keywords

1,3,4-Oxadiazole
Antimicrobial
Antiprotozoal
Quinoxaline

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10.1016/j.ijantimicag.2017.04.016

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Patel, N. B., Patel, J. N., Purohit, A. C., Patel, V. M., Rajani, D. P., Moo-Puc, R., Lopez-Cedillo, J. C., Nogueda-Torres, B., & Rivera, G. (2017). In vitro and in vivo assessment of newer quinoxaline–oxadiazole hybrids as antimicrobial and antiprotozoal agents. International Journal of Antimicrobial Agents, 50(3), 413-418. https://doi.org/10.1016/j.ijantimicag.2017.04.016

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title = "In vitro and in vivo assessment of newer quinoxaline–oxadiazole hybrids as antimicrobial and antiprotozoal agents",

abstract = "A new series of N-(substituted-phenyl)-2-[5-(quinoxalin-2-yloxymethyl)-[1,3,4] oxadiazol-2-ylsulfanyl]-acetamides (5a–o) was designed and synthesised from the parent compound 2-hydroxy quinoxaline (1) through a multistep reaction sequence and was characterised by spectral and elemental analyses. All of the compounds synthesised were evaluated for their antimicrobial and antiprotozoal activities. The results revealed that quinoxaline-based 1,3,4-oxadiazoles displayed promising antibacterial, antifungal and anti-Trypanosoma cruzi activities compared with reference drugs, particularly the lead compound 5l in a short-term in vivo model in T. cruzi.",

keywords = "1,3,4-Oxadiazole, Antimicrobial, Antiprotozoal, Quinoxaline",

author = "Patel, {Navin B.} and Patel, {Jignesh N.} and Purohit, {Amit C.} and Patel, {Vatsal M.} and Rajani, {Dhanji P.} and Rosa Moo-Puc and Lopez-Cedillo, {Julio Cesar} and Benjamin Nogueda-Torres and Gildardo Rivera",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier B.V. and International Society of Chemotherapy",

year = "2017",

month = sep,

doi = "10.1016/j.ijantimicag.2017.04.016",

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volume = "50",

pages = "413--418",

journal = "International Journal of Antimicrobial Agents",

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TY - JOUR

T1 - In vitro and in vivo assessment of newer quinoxaline–oxadiazole hybrids as antimicrobial and antiprotozoal agents

AU - Patel, Navin B.

AU - Patel, Jignesh N.

AU - Purohit, Amit C.

AU - Patel, Vatsal M.

AU - Rajani, Dhanji P.

AU - Moo-Puc, Rosa

AU - Lopez-Cedillo, Julio Cesar

AU - Nogueda-Torres, Benjamin

AU - Rivera, Gildardo

PY - 2017/9

Y1 - 2017/9

N2 - A new series of N-(substituted-phenyl)-2-[5-(quinoxalin-2-yloxymethyl)-[1,3,4] oxadiazol-2-ylsulfanyl]-acetamides (5a–o) was designed and synthesised from the parent compound 2-hydroxy quinoxaline (1) through a multistep reaction sequence and was characterised by spectral and elemental analyses. All of the compounds synthesised were evaluated for their antimicrobial and antiprotozoal activities. The results revealed that quinoxaline-based 1,3,4-oxadiazoles displayed promising antibacterial, antifungal and anti-Trypanosoma cruzi activities compared with reference drugs, particularly the lead compound 5l in a short-term in vivo model in T. cruzi.

AB - A new series of N-(substituted-phenyl)-2-[5-(quinoxalin-2-yloxymethyl)-[1,3,4] oxadiazol-2-ylsulfanyl]-acetamides (5a–o) was designed and synthesised from the parent compound 2-hydroxy quinoxaline (1) through a multistep reaction sequence and was characterised by spectral and elemental analyses. All of the compounds synthesised were evaluated for their antimicrobial and antiprotozoal activities. The results revealed that quinoxaline-based 1,3,4-oxadiazoles displayed promising antibacterial, antifungal and anti-Trypanosoma cruzi activities compared with reference drugs, particularly the lead compound 5l in a short-term in vivo model in T. cruzi.

KW - 1,3,4-Oxadiazole

KW - Antimicrobial

KW - Antiprotozoal

KW - Quinoxaline

UR - http://www.scopus.com/inward/record.url?scp=85028310172&partnerID=8YFLogxK

U2 - 10.1016/j.ijantimicag.2017.04.016

DO - 10.1016/j.ijantimicag.2017.04.016

M3 - Artículo

C2 - 28687457

SN - 0924-8579

VL - 50

SP - 413

EP - 418

JO - International Journal of Antimicrobial Agents

JF - International Journal of Antimicrobial Agents

IS - 3

ER -

In vitro and in vivo assessment of newer quinoxaline–oxadiazole hybrids as antimicrobial and antiprotozoal agents

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