Immunomodulatory properties of Mycoplasma pulmonis. I. Characterization of the immunomodulatory activity

A. Romero-Rojas, C. Ponce-Hernández, A. Ciprián, S. Estrada-Parra, J. W. Hadden

Research output: Contribution to journalArticle

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Abstract

For many years, it has been recognized that Mycoplasma infection affects the host's immune system in different ways. In this work, experiments were performed to characterize the influence of Mycoplasma pulmonis infection on various immunological parameters and to follow the kinetics of their variations. A Balb/c mouse model was used to assess hematological evaluations, changes in spleen weight, antibody responses against sheep erythrocytes, neutrophil phagocytosis, colloidal carbon clearance, and anti-Mycoplasma antibody responses. At the hematological level, infected animals were found to have significantly increased total lymphocyte and polymorphonuclear leukocyte counts and an augmentation in spleen weight. Seven days after Mycoplasma infection, antibody responses against sheep erythrocytes were considerably diminished, and at days 7 and 14 after infection, phagocytic activity was also reduced. After 1 week of infection, the colloidal carbon clearance pattern was decreased, and during the whole infectious process, anti-Mycoplasma antibody titers were found to be low. Results from this part of research show a persistent infection that does not resolve in a short period, which is associated with a general dysfunction in the immune system and poor immune responses against several different antigens. © 2001 Elsevier Science B.V. All rights reserved.
Original languageAmerican English
Pages (from-to)1679-1688
Number of pages1510
JournalInternational Immunopharmacology
DOIs
StatePublished - 1 Sep 2001

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Mycoplasma pulmonis
Mycoplasma Infections
Antibody Formation
Mycoplasma
Anti-Idiotypic Antibodies
Immune System
Sheep
Neutrophils
Carbon
Spleen
Infection
Erythrocytes
Weights and Measures
Leukocyte Count
Phagocytosis
Lymphocytes
Antigens
Research

Cite this

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title = "Immunomodulatory properties of Mycoplasma pulmonis. I. Characterization of the immunomodulatory activity",
abstract = "For many years, it has been recognized that Mycoplasma infection affects the host's immune system in different ways. In this work, experiments were performed to characterize the influence of Mycoplasma pulmonis infection on various immunological parameters and to follow the kinetics of their variations. A Balb/c mouse model was used to assess hematological evaluations, changes in spleen weight, antibody responses against sheep erythrocytes, neutrophil phagocytosis, colloidal carbon clearance, and anti-Mycoplasma antibody responses. At the hematological level, infected animals were found to have significantly increased total lymphocyte and polymorphonuclear leukocyte counts and an augmentation in spleen weight. Seven days after Mycoplasma infection, antibody responses against sheep erythrocytes were considerably diminished, and at days 7 and 14 after infection, phagocytic activity was also reduced. After 1 week of infection, the colloidal carbon clearance pattern was decreased, and during the whole infectious process, anti-Mycoplasma antibody titers were found to be low. Results from this part of research show a persistent infection that does not resolve in a short period, which is associated with a general dysfunction in the immune system and poor immune responses against several different antigens. {\circledC} 2001 Elsevier Science B.V. All rights reserved.",
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Immunomodulatory properties of Mycoplasma pulmonis. I. Characterization of the immunomodulatory activity. / Romero-Rojas, A.; Ponce-Hernández, C.; Ciprián, A.; Estrada-Parra, S.; Hadden, J. W.

In: International Immunopharmacology, 01.09.2001, p. 1679-1688.

Research output: Contribution to journalArticle

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