Sera from patients with scleroderma have been found to have anti RNA antibodies which react with human serum albumin (HSA) coupled uridine and uridine monophosphate (UMP) and are inhibited by uracil, uridine and UMP. Scleroderma sera react uniformly with 5' polyuridylic acid (poly(U)) and fail to react with polyadenylic, polyuridylic acid (poly(A) . poly(U)) which is also indicative of their uracil specificity. Anti RNA antibodies found in systemic lupus erythematosus (SLE) are immunochemically different from those found in scleroderma in that, instead of being uniformly specific to uracil, they are markedly heterogeneous and may react with uracil, uridine and/or UMP. SLE sera frequently react with poly(A) . poly(U), indicating also their ability to recognize the double helical structure of double stranded RNA. Thirty seven scleroderma and thirty four SLE sera from as many patients with either of these conditions were tested against HSA coupled, uridine containing monosphophoric dinucleotides in an attempt to characterize further their anti RNA antibodies.
|Number of pages||6|
|State||Published - 1976|