TY - JOUR
T1 - Immunity to influenza
T2 - Impact of obesity
AU - Rojas-Osornio, Sandra Angélica
AU - Cruz-Hernández, Teresita Rocío
AU - Drago-Serrano, Maria Elisa
AU - Campos-Rodríguez, Rafael
N1 - Publisher Copyright:
© 2019
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Obesity is a health concern that is recognized as a critical factor for vulnerability to influenza A/pdmH1N1 virus infection, with epidemiological and clinical impacts. In humans, obesity induces disturbances in inflammatory and immune responses to the influenza virus and in some cases, this leads to severe complications, with fatal outcomes. Obesity impairs immunity by altering the response of cytokines, resulting in a decrease in the cytotoxic cell response of immunocompetent cells which have a key anti-viral role. Additionally, obesity seems to disturb the balance of endocrine hormones, such as leptin, that affect the interplay between metabolic and immune systems. This contribution focuses on reviewing the current epidemiologic data for the immune response to immunity in obese humans and animal models. In doing so, we aim to provide potential mechanisms to enhance immunity to influenza A/pdmH1N1 virus infection and protective factors in obese people.
AB - Obesity is a health concern that is recognized as a critical factor for vulnerability to influenza A/pdmH1N1 virus infection, with epidemiological and clinical impacts. In humans, obesity induces disturbances in inflammatory and immune responses to the influenza virus and in some cases, this leads to severe complications, with fatal outcomes. Obesity impairs immunity by altering the response of cytokines, resulting in a decrease in the cytotoxic cell response of immunocompetent cells which have a key anti-viral role. Additionally, obesity seems to disturb the balance of endocrine hormones, such as leptin, that affect the interplay between metabolic and immune systems. This contribution focuses on reviewing the current epidemiologic data for the immune response to immunity in obese humans and animal models. In doing so, we aim to provide potential mechanisms to enhance immunity to influenza A/pdmH1N1 virus infection and protective factors in obese people.
KW - Influenza A/pdmH1N1 virus
KW - Leptin
KW - Obesity
KW - Vaccine
UR - http://www.scopus.com/inward/record.url?scp=85072250203&partnerID=8YFLogxK
U2 - 10.1016/j.orcp.2019.05.003
DO - 10.1016/j.orcp.2019.05.003
M3 - Artículo de revisión
C2 - 31542241
AN - SCOPUS:85072250203
SN - 1871-403X
VL - 13
SP - 419
EP - 429
JO - Obesity Research and Clinical Practice
JF - Obesity Research and Clinical Practice
IS - 5
ER -
