Identification of Chlamydia trachomatis genotypes in newborns with respiratory distress

Translated title of the contribution: Identification of Chlamydia trachomatis genotypes in newborns with respiratory distress

Melissa D. González-Fernández, Marco A. Escarcega-Tame, Marcela López-Hurtado, Verónica R. Flores-Salazar, Marcos R. Escobedo-Guerra, Silvia Giono-Cerezo, Fernando M. Guerra-Infante

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Introduction: One hundred thirty million Chlamydia trachomatis infections are reported worldwide each year. Nineteen serotypes of this pathogen can cause infection in pregnant women and neonates. The distribution of these genotypes in newborns with respiratory infections in Mexico is unknown. Material and methods: We tested 1062 bronchial lavage samples from neonates with respiratory distress syndrome for Chlamydia infection. The diagnosis of Chlamydia was made by plasmid detection with an in-house PCR assay, and genotypes were identified using a PCR-RFLP assay for the ompA gene. Results: The genotyping of 40 strains identified 14 as I/Ia (35%), 13 as E (32.5%), 7 as D (17.5%), 5 as F (12.5%), and 1 as L2 (2.5%). The relative risk analysis showed that genotype D was associated with neonatal sepsis (RR, 5.83; 95% confidence interval [CI], 1.51-25.985; P < .02), while the I/Ia genotype was significantly associated with chorioamnionitis in the mother (2.8; 95% CI, 1.4–5.5; P < .05). Conclusions: Although Chlamydia trachomatis genotypes I/Ia and E of were the strains involved most frequently in respiratory infections in Mexican neonates, 80% of patients with genotype F developed respiratory disease. In contrast, genotype D was associated with neonatal sepsis, and genotype I/Ia with chorioamnionitis.

Translated title of the contributionIdentification of Chlamydia trachomatis genotypes in newborns with respiratory distress
Original languageEnglish
Pages (from-to)436-445
Number of pages10
JournalAnales de Pediatria
Volume98
Issue number6
DOIs
StatePublished - Jun 2023

Keywords

  • Atypical pneumonia
  • Chlamydia and pregnancy
  • Chlamydia trachomatis
  • Chlamydia trachomatis genotypes
  • Neonatal Chlamydia infection
  • Pneumonia caused by Chlamydia

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