TY - JOUR
T1 - Hypothyroidism induces selective oxidative stress in amygdala and hippocampus of rat
AU - Cano-Europa, Edgar
AU - Pérez-Severiano, Francisca
AU - Vergara, Paula
AU - Ortiz-Butrón, Rocío
AU - Ríos, Camilo
AU - Segovia, José
AU - Pacheco-Rosado, Jorge
N1 - Funding Information:
Acknowledgments This work was supported by SIP-IPN 20070734, CONACyT 52253 (J.P.-R.), CONACyT 53220-M (F.P.-S.) and CONACyT 54756 (J.S.). R.O.-B. and J.P.-R. are fellows of EDI-IPN and DEDICT-COFAA-IPN. E.C.-E. is fellow of CONACYT. We thank Dr. M Hernández (Cinvestav) for the kind gift of the β-actin antibody.
PY - 2008/9
Y1 - 2008/9
N2 - The effects of hypothyroidism on lipid peroxidation (LP), reactive oxygen species (ROS), and nitric oxide synthase (NOS), levels and expression, in rat brain were examined. Hypothyroidism was induced by administering methimazole in drinking water (60 mg/kg/day). In striatum, motor cortex and cerebellum of hypothyroid rats LP was not modified, whereas LP and ROS increased in amygdala and hippocampus of hypothyroid rats at the third week of treatment with methimazole as compared to euthyroid group values. Regarding NOS participation, only hippocampal constitutive-NOS activity was increased, accompanied by an augmentation in nNOS expression. Results show that hypothyroidism induces selective oxidative stress in both the hippocampus and amygdala, where the nitrergic system is involved.
AB - The effects of hypothyroidism on lipid peroxidation (LP), reactive oxygen species (ROS), and nitric oxide synthase (NOS), levels and expression, in rat brain were examined. Hypothyroidism was induced by administering methimazole in drinking water (60 mg/kg/day). In striatum, motor cortex and cerebellum of hypothyroid rats LP was not modified, whereas LP and ROS increased in amygdala and hippocampus of hypothyroid rats at the third week of treatment with methimazole as compared to euthyroid group values. Regarding NOS participation, only hippocampal constitutive-NOS activity was increased, accompanied by an augmentation in nNOS expression. Results show that hypothyroidism induces selective oxidative stress in both the hippocampus and amygdala, where the nitrergic system is involved.
KW - Lipid peroxidation
KW - Methimazole
KW - Oxidative damage
UR - http://www.scopus.com/inward/record.url?scp=50049119360&partnerID=8YFLogxK
U2 - 10.1007/s11011-008-9099-0
DO - 10.1007/s11011-008-9099-0
M3 - Artículo
C2 - 18683039
SN - 0885-7490
VL - 23
SP - 275
EP - 287
JO - Metabolic Brain Disease
JF - Metabolic Brain Disease
IS - 3
ER -