TY - JOUR
T1 - Hypothyroid offspring replacement with euthyroid wet nurses during lactation improves thyroid programming without modifying metabolic programming
AU - Tapia-Martínez, Jorge
AU - Franco-Colín, Margarita
AU - Ortiz-Butron, Rocio
AU - Pineda-Reynoso, Marisol
AU - Cano-Europa, Edgar
N1 - Publisher Copyright:
© AE&M all rights reserved.
PY - 2019/6
Y1 - 2019/6
N2 - Objective: Determine the milk quality effect during lactation on the metabolic and thyroid programming of hypothyroid offspring. Materials and methods: Ten-week-old female Wistar rats were divided into two groups: Euthyroid and thyroidectomy-caused hypothyroidism. The rats were matted and, one day after birth, the pups were divided into three groups: Euthyroid offspring (EO), hypothyroid offspring (HO) and hypothyroid with a euthyroid replacement wet nurse (HRO). During lactation, the milk quality and offspring body length were evaluated. The body weight and energy intake were determined on a weekly basis, as well as the metabolic profile at the prepubertal (P35-36) and postpubertal (P55-56) ages. At P56, the animals were sacrificed, the adipose tissues were weighed and the thyroid glands were dissected for histological processing. Results: The milk of the hypothyroid wet nurse decreases proteins (16-26%), lipids (22-29%) and lactate (22-37%) with respect to euthyroid. The HO has a lower body weight gain (23-33%), length (11-13%) and energy intake (15-21%). In addition, HO presents impaired fasting glucose and dyslipidemia, as well as a reduction in seric thyroid hormone (18-34%), adipose reserves (26-68%) and thyroid gland weight (25-34%). The HO present thyroid gland cytoarchitecture alteration. The HRO develop the same metabolic alterations as the HO. However, the thyroid gland dysfunction was partially prevented because the HRO improved under about 10% of the serum thyroid hormone concentration, the thyroid gland weight although histological glandular changes presented. Conclusions: The replacement of hypothyroid offspring with a euthyroid wet nurse during lactation can improve the thyroid programming without modifying metabolic programming.
AB - Objective: Determine the milk quality effect during lactation on the metabolic and thyroid programming of hypothyroid offspring. Materials and methods: Ten-week-old female Wistar rats were divided into two groups: Euthyroid and thyroidectomy-caused hypothyroidism. The rats were matted and, one day after birth, the pups were divided into three groups: Euthyroid offspring (EO), hypothyroid offspring (HO) and hypothyroid with a euthyroid replacement wet nurse (HRO). During lactation, the milk quality and offspring body length were evaluated. The body weight and energy intake were determined on a weekly basis, as well as the metabolic profile at the prepubertal (P35-36) and postpubertal (P55-56) ages. At P56, the animals were sacrificed, the adipose tissues were weighed and the thyroid glands were dissected for histological processing. Results: The milk of the hypothyroid wet nurse decreases proteins (16-26%), lipids (22-29%) and lactate (22-37%) with respect to euthyroid. The HO has a lower body weight gain (23-33%), length (11-13%) and energy intake (15-21%). In addition, HO presents impaired fasting glucose and dyslipidemia, as well as a reduction in seric thyroid hormone (18-34%), adipose reserves (26-68%) and thyroid gland weight (25-34%). The HO present thyroid gland cytoarchitecture alteration. The HRO develop the same metabolic alterations as the HO. However, the thyroid gland dysfunction was partially prevented because the HRO improved under about 10% of the serum thyroid hormone concentration, the thyroid gland weight although histological glandular changes presented. Conclusions: The replacement of hypothyroid offspring with a euthyroid wet nurse during lactation can improve the thyroid programming without modifying metabolic programming.
KW - Congenital hypothyroidism
KW - Lactation
KW - Metabolic programming
KW - Thyroid gland
KW - Thyroid programming
UR - http://www.scopus.com/inward/record.url?scp=85071613591&partnerID=8YFLogxK
U2 - 10.20945/2359-3997000000132
DO - 10.20945/2359-3997000000132
M3 - Artículo
C2 - 31066757
AN - SCOPUS:85071613591
SN - 2359-3997
VL - 63
SP - 199
EP - 207
JO - Archives of Endocrinology and Metabolism
JF - Archives of Endocrinology and Metabolism
IS - 3
ER -