TY - JOUR
T1 - Hypothermia elicited by haloperidol in rats with hypothalamic lesions
AU - de la Cruz, Fidel
PY - 1988/1
Y1 - 1988/1
N2 - In a previous paper it was reported that haloperidol plus morphine produces a marked hypothermia, whereas each drug alone had only negligible effects on temperature. A large hypothalamic lesion produced variable hypothermia lasting several days. After the lesion, rats could be classified in two groups: A-those which had marked decreases of colonic temperature (from 3 to 7°C) and B-those which had a slight decrease (about 1°C). The administration of haloperidol, which in normal rats has no effect on temperature, elicited in hypothalamic-lesion rats, whether or not they were already hypothermic, a marked decrease in temperature lasting several hours. Rats of group B showed a faster decrease as well as a faster recovery of temperature than those of group A. It was concluded that the hypothalamic lesions produced an effect equivalent to an increase in opioid activity and/or a decrease in dopaminergic activity.
AB - In a previous paper it was reported that haloperidol plus morphine produces a marked hypothermia, whereas each drug alone had only negligible effects on temperature. A large hypothalamic lesion produced variable hypothermia lasting several days. After the lesion, rats could be classified in two groups: A-those which had marked decreases of colonic temperature (from 3 to 7°C) and B-those which had a slight decrease (about 1°C). The administration of haloperidol, which in normal rats has no effect on temperature, elicited in hypothalamic-lesion rats, whether or not they were already hypothermic, a marked decrease in temperature lasting several hours. Rats of group B showed a faster decrease as well as a faster recovery of temperature than those of group A. It was concluded that the hypothalamic lesions produced an effect equivalent to an increase in opioid activity and/or a decrease in dopaminergic activity.
UR - http://www.scopus.com/inward/record.url?scp=0023869733&partnerID=8YFLogxK
U2 - 10.1016/0014-4886(88)90143-4
DO - 10.1016/0014-4886(88)90143-4
M3 - Artículo
SN - 0014-4886
VL - 99
SP - 234
EP - 238
JO - Experimental Neurology
JF - Experimental Neurology
IS - 1
ER -