TY - JOUR
T1 - Hypophysectomy and neurointermediate pituitary lobectomy decrease humoral immune responses to T-independent and T-dependent antigens
AU - Quintanar-Stephano, A.
AU - Abarca-Rojano, E.
AU - Jarillo-Luna, R. A.
AU - Rivera-Aguilar, V.
AU - Ventura-Juárez, J.
AU - Berczi, I.
AU - Kovacs, K.
AU - Campos-Rodríguez, R.
N1 - Funding Information:
The authors wish to thanks to A. Organista-Esparza, J.L. Ponce-Márquez, C.A. Ponce-Gallegos, and B. Allan-Larsen for the skillful technical assistance. This work was supported by UAA PIFF 05-4N grant México and SIP-IPN. The authors declare that there is no conflict of interest that would interfere with the impartiality of this research work.
PY - 2010/3
Y1 - 2010/3
N2 - In rats, hypophysectomy (HYPOX) or neurointermediate pituitary lobectomy (NIL) reduce humoral and cell-mediated immune responses. However, to our knowledge, the differences in the effects of anterior versus posterior pituitary hormones on the immune responses have not been studied to date. We compared in rats, the effects of sham surgery (SHAM), HYPOX, and NIL on humoral immune responses to T cell-independent (TI) type 1 antigen DNP-LPS and to TI type 2 antigen DNP-FICOLL, as well as to T cell-dependent (TD) antigens ovalbumin (OVA) and bovine serum albumin (BSA). The results showed that: (1) both HYPOX and NIL induced a similar and significant decrease in IgM responses towards TI-1 antigens, (2) NIL but not HYPOX induced a decreased IgM response to TI-2 antigens, and (3) both HYPOX and NIL induced similar and significant decrease in IgG responses to TI-2 antigens. Compared with the SHAM group, IgM responses to both TD antigens did not change in HYPOX and NIL animals, whereas the IgG responses to OVA and BSA significantly decreased in HYPOX and NIL animals. These results indicate that hormones of the anterior and posterior pituitary play their own role in the regulation of humoral immune responses.
AB - In rats, hypophysectomy (HYPOX) or neurointermediate pituitary lobectomy (NIL) reduce humoral and cell-mediated immune responses. However, to our knowledge, the differences in the effects of anterior versus posterior pituitary hormones on the immune responses have not been studied to date. We compared in rats, the effects of sham surgery (SHAM), HYPOX, and NIL on humoral immune responses to T cell-independent (TI) type 1 antigen DNP-LPS and to TI type 2 antigen DNP-FICOLL, as well as to T cell-dependent (TD) antigens ovalbumin (OVA) and bovine serum albumin (BSA). The results showed that: (1) both HYPOX and NIL induced a similar and significant decrease in IgM responses towards TI-1 antigens, (2) NIL but not HYPOX induced a decreased IgM response to TI-2 antigens, and (3) both HYPOX and NIL induced similar and significant decrease in IgG responses to TI-2 antigens. Compared with the SHAM group, IgM responses to both TD antigens did not change in HYPOX and NIL animals, whereas the IgG responses to OVA and BSA significantly decreased in HYPOX and NIL animals. These results indicate that hormones of the anterior and posterior pituitary play their own role in the regulation of humoral immune responses.
KW - Humoral responses
KW - Hypophysectomy
KW - Neurohypophysectomy
KW - Pituitary hormones
KW - T-independent and T-dependent antigens
UR - http://www.scopus.com/inward/record.url?scp=77955120389&partnerID=8YFLogxK
U2 - 10.1007/s13105-010-0004-z
DO - 10.1007/s13105-010-0004-z
M3 - Artículo
C2 - 20407859
SN - 1138-7548
VL - 66
SP - 7
EP - 13
JO - Journal of Physiology and Biochemistry
JF - Journal of Physiology and Biochemistry
IS - 1
ER -