TY - JOUR
T1 - Hypolipidemic effect of trixis angustifolia aqueous extract on triton WR-1339- And high-fat diet-induced hyperlipidemic mice
AU - Salazar-Gómez, Anuar
AU - Sánchez-Chávez, Anahí C.
AU - Zepeda-Vallejo, Gerardo
AU - Chamorro-Cevallos, Germán
AU - Garduño-Siciliano, Leticia
AU - Vargas-Díaz, Elena
N1 - Publisher Copyright:
© The Author(s) 2019.
PY - 2019
Y1 - 2019
N2 - The aim of the present study was to evaluate the hypolipidemic effect of Trixis angustifolia aqueous extract (TxAE) on Triton WR- 1339- and high-fat diet-induced hyperlipidemic mice. In the Triton model, treatment with TxAE at 100 and 200 mg/kg body weight produced a significant decrease in triglycerides and very low-density lipoprotein levels and a significant increase in high-density lipoprotein (HDL). Similarly, administration of TxAE along with the high-fat diet induced a significant decrease in serum total cholesterol, low-density lipoproteins, and increase in HDL. In addition, a phytochemical study of TxAE led to the isolation of 2 previously described compounds: pebrellin and xanthomicrol. This is the first time that these compounds have been identified in a plant extract with hypolipidemic effect. The results suggest the possible therapeutic potential of TxAE as a hypolipidemic agent supporting the usage of T. angustifolia as a traditional medicine.
AB - The aim of the present study was to evaluate the hypolipidemic effect of Trixis angustifolia aqueous extract (TxAE) on Triton WR- 1339- and high-fat diet-induced hyperlipidemic mice. In the Triton model, treatment with TxAE at 100 and 200 mg/kg body weight produced a significant decrease in triglycerides and very low-density lipoprotein levels and a significant increase in high-density lipoprotein (HDL). Similarly, administration of TxAE along with the high-fat diet induced a significant decrease in serum total cholesterol, low-density lipoproteins, and increase in HDL. In addition, a phytochemical study of TxAE led to the isolation of 2 previously described compounds: pebrellin and xanthomicrol. This is the first time that these compounds have been identified in a plant extract with hypolipidemic effect. The results suggest the possible therapeutic potential of TxAE as a hypolipidemic agent supporting the usage of T. angustifolia as a traditional medicine.
KW - Aqueous extract
KW - Hyperlipidemia
KW - Hypolipidemic
KW - Triton WR-1339
KW - Trixis angustifolia
UR - http://www.scopus.com/inward/record.url?scp=85069721374&partnerID=8YFLogxK
U2 - 10.1177/1934578X19864218
DO - 10.1177/1934578X19864218
M3 - Artículo
AN - SCOPUS:85069721374
SN - 1934-578X
VL - 14
JO - Natural Product Communications
JF - Natural Product Communications
IS - 7
ER -