Hypolipidaemic activity of dimethoxy unconjugated propenyl side-chain analogs of α-asarone in mice

Germán Chamorro, Leticia Garduño, Adrian Sánchez, Fernando Labarrios, María Salazar, Elizdath Martínez, Francisco Díaz, Joaquín Tamariz

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Abstract

The hypolipidaemic activity of several dimethoxy unconjugated propenyl side-chain analogs of α-asarone were investigated in hyperlipidaemic mice after six days of treatment. Eugenol and the α-asarone analog with amino groups on the C-4 position of the aromatic ring were observed to be the most effective hypolipidaemic agents at the dose of 80 mg/kg/day p.o. These compounds significantly lowered total serum cholesterol, low density lipoprotein (LDL-cholesterol), and triglycerides content. On the other hand, high density lipoprotein (HDL-cholesterol) was increased by administration of these hypolipidaemic agents. The ability to modulate the levels of these lipids suggests that these agents could be effective in the treatment of hyperlipidaemic states. These compounds appeared to be safe when administered at an oral dose of 80 mg/kg/day, which is within the therapeutic range in mice.
Original languageAmerican English
Pages (from-to)105-108
Number of pages94
JournalDrug Development Research
DOIs
StatePublished - 1 Feb 1998

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Hypolipidemic Agents
Cholesterol
LDL Cholesterol
HDL Cholesterol
Lipoproteins
Eugenol
serum
lipid
Lipids
Serum
low density lipoprotein triglyceride
asarone
dose
Therapeutics

Cite this

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title = "Hypolipidaemic activity of dimethoxy unconjugated propenyl side-chain analogs of α-asarone in mice",
abstract = "The hypolipidaemic activity of several dimethoxy unconjugated propenyl side-chain analogs of α-asarone were investigated in hyperlipidaemic mice after six days of treatment. Eugenol and the α-asarone analog with amino groups on the C-4 position of the aromatic ring were observed to be the most effective hypolipidaemic agents at the dose of 80 mg/kg/day p.o. These compounds significantly lowered total serum cholesterol, low density lipoprotein (LDL-cholesterol), and triglycerides content. On the other hand, high density lipoprotein (HDL-cholesterol) was increased by administration of these hypolipidaemic agents. The ability to modulate the levels of these lipids suggests that these agents could be effective in the treatment of hyperlipidaemic states. These compounds appeared to be safe when administered at an oral dose of 80 mg/kg/day, which is within the therapeutic range in mice.",
author = "Germ{\'a}n Chamorro and Leticia Gardu{\~n}o and Adrian S{\'a}nchez and Fernando Labarrios and Mar{\'i}a Salazar and Elizdath Mart{\'i}nez and Francisco D{\'i}az and Joaqu{\'i}n Tamariz",
year = "1998",
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T1 - Hypolipidaemic activity of dimethoxy unconjugated propenyl side-chain analogs of α-asarone in mice

AU - Chamorro, Germán

AU - Garduño, Leticia

AU - Sánchez, Adrian

AU - Labarrios, Fernando

AU - Salazar, María

AU - Martínez, Elizdath

AU - Díaz, Francisco

AU - Tamariz, Joaquín

PY - 1998/2/1

Y1 - 1998/2/1

N2 - The hypolipidaemic activity of several dimethoxy unconjugated propenyl side-chain analogs of α-asarone were investigated in hyperlipidaemic mice after six days of treatment. Eugenol and the α-asarone analog with amino groups on the C-4 position of the aromatic ring were observed to be the most effective hypolipidaemic agents at the dose of 80 mg/kg/day p.o. These compounds significantly lowered total serum cholesterol, low density lipoprotein (LDL-cholesterol), and triglycerides content. On the other hand, high density lipoprotein (HDL-cholesterol) was increased by administration of these hypolipidaemic agents. The ability to modulate the levels of these lipids suggests that these agents could be effective in the treatment of hyperlipidaemic states. These compounds appeared to be safe when administered at an oral dose of 80 mg/kg/day, which is within the therapeutic range in mice.

AB - The hypolipidaemic activity of several dimethoxy unconjugated propenyl side-chain analogs of α-asarone were investigated in hyperlipidaemic mice after six days of treatment. Eugenol and the α-asarone analog with amino groups on the C-4 position of the aromatic ring were observed to be the most effective hypolipidaemic agents at the dose of 80 mg/kg/day p.o. These compounds significantly lowered total serum cholesterol, low density lipoprotein (LDL-cholesterol), and triglycerides content. On the other hand, high density lipoprotein (HDL-cholesterol) was increased by administration of these hypolipidaemic agents. The ability to modulate the levels of these lipids suggests that these agents could be effective in the treatment of hyperlipidaemic states. These compounds appeared to be safe when administered at an oral dose of 80 mg/kg/day, which is within the therapeutic range in mice.

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