Hyperthermia effect on phantom of breast carcinoma tissue induced by MN₃O₄ nanoparticles synthesized by one-step spray pyrolysis method

In this work, the synthesis of manganese oxide nanoparticles was achieved by one-step spray pyrolysis method. The nanoparticles were synthesized just from MnC_l2 aqueous solution. The solution was nebulized to a Si substrate placed at 400 °C for 1, 5 10 and 20 min and transported at a 0.1 L /min rate in a Nitrogen flux. The X-ray diffraction confirms tetragonal Mn₃O₄ as the unique phase in the whole sample. The scanning electron microscopy images proved the achievement of irregular nanoparticles with an average diameter of 280 nm experimentally determined by dynamic light scattering. Energy dispersive X-ray and Raman spectroscopy confirmed that the nanoparticles were obtained with Mn₃O₄ single-phase and the employed methodology prevented any contamination. The nanoparticles proved to induce temperature enhancement on artificial breast tissue by exposition to microwave radiation by achieving an increase in temperature around 8%.