Glutathione, C and E vitamins protect on chromium-induced acute renal damage in rat

María Leticia Ávila R, María Estela Meléndez Camargo

Research output: Contribution to journalArticleResearchpeer-review

Abstract

In Wistar female adult rats acute renal failure (ARF) was induced with a single dose of potassium chromate (20 mg/kg, subcutaneous). Four groups, control group and three chromium treated-groups, one of them was received vitamins C (200 mg/kg) and vitamin E (alfa-tocopherol, 100 mg/kg) and another glutathione (50 mg/kg) per os. In urine and blood samples obtained on days 1, 3, 5, 10 and 14, creatinine and sodium concentration were measured. In urine proteins and glucose were also measured. PAH uptake by cortical renal tissue was determined. In ARF, results revealed proximal renal function altered, increased creatinine serum and decreased glomerular filtration. In the antioxidants treated-groups proximal function were preserved and did not prevent totally glomerular and distal dysfunction. The recovery was faster in the presence of the antioxidants ones.
Original languageAmerican English
Pages (from-to)35-41
Number of pages30
JournalRevista Mexicana de Ciencias Farmaceuticas
StatePublished - 1 Jan 2009

Fingerprint

tocopherol
glutathione
ascorbic acid
Vitamins
Chromium
Antioxidants
Vitamin E
Acute Kidney Injury
Ascorbic Acid
rats
Glutathione
Rats
chromium
Creatinine
Urine
creatinine
damage
Kidney
Chromates
urine

Cite this

@article{bbd0b7d1e5744dd2854931b1d879febe,
title = "Glutathione, C and E vitamins protect on chromium-induced acute renal damage in rat",
abstract = "In Wistar female adult rats acute renal failure (ARF) was induced with a single dose of potassium chromate (20 mg/kg, subcutaneous). Four groups, control group and three chromium treated-groups, one of them was received vitamins C (200 mg/kg) and vitamin E (alfa-tocopherol, 100 mg/kg) and another glutathione (50 mg/kg) per os. In urine and blood samples obtained on days 1, 3, 5, 10 and 14, creatinine and sodium concentration were measured. In urine proteins and glucose were also measured. PAH uptake by cortical renal tissue was determined. In ARF, results revealed proximal renal function altered, increased creatinine serum and decreased glomerular filtration. In the antioxidants treated-groups proximal function were preserved and did not prevent totally glomerular and distal dysfunction. The recovery was faster in the presence of the antioxidants ones.",
author = "{{\'A}vila R}, {Mar{\'i}a Leticia} and {Mel{\'e}ndez Camargo}, {Mar{\'i}a Estela}",
year = "2009",
month = "1",
day = "1",
language = "American English",
pages = "35--41",
journal = "Revista Mexicana de Ciencias Farmaceuticas",
issn = "1027-3956",
publisher = "Asociacion Farmaceutica Mexicana A.C.",

}

Glutathione, C and E vitamins protect on chromium-induced acute renal damage in rat. / Ávila R, María Leticia; Meléndez Camargo, María Estela.

In: Revista Mexicana de Ciencias Farmaceuticas, 01.01.2009, p. 35-41.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Glutathione, C and E vitamins protect on chromium-induced acute renal damage in rat

AU - Ávila R, María Leticia

AU - Meléndez Camargo, María Estela

PY - 2009/1/1

Y1 - 2009/1/1

N2 - In Wistar female adult rats acute renal failure (ARF) was induced with a single dose of potassium chromate (20 mg/kg, subcutaneous). Four groups, control group and three chromium treated-groups, one of them was received vitamins C (200 mg/kg) and vitamin E (alfa-tocopherol, 100 mg/kg) and another glutathione (50 mg/kg) per os. In urine and blood samples obtained on days 1, 3, 5, 10 and 14, creatinine and sodium concentration were measured. In urine proteins and glucose were also measured. PAH uptake by cortical renal tissue was determined. In ARF, results revealed proximal renal function altered, increased creatinine serum and decreased glomerular filtration. In the antioxidants treated-groups proximal function were preserved and did not prevent totally glomerular and distal dysfunction. The recovery was faster in the presence of the antioxidants ones.

AB - In Wistar female adult rats acute renal failure (ARF) was induced with a single dose of potassium chromate (20 mg/kg, subcutaneous). Four groups, control group and three chromium treated-groups, one of them was received vitamins C (200 mg/kg) and vitamin E (alfa-tocopherol, 100 mg/kg) and another glutathione (50 mg/kg) per os. In urine and blood samples obtained on days 1, 3, 5, 10 and 14, creatinine and sodium concentration were measured. In urine proteins and glucose were also measured. PAH uptake by cortical renal tissue was determined. In ARF, results revealed proximal renal function altered, increased creatinine serum and decreased glomerular filtration. In the antioxidants treated-groups proximal function were preserved and did not prevent totally glomerular and distal dysfunction. The recovery was faster in the presence of the antioxidants ones.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=67649637270&origin=inward

UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=67649637270&origin=inward

M3 - Article

SP - 35

EP - 41

JO - Revista Mexicana de Ciencias Farmaceuticas

JF - Revista Mexicana de Ciencias Farmaceuticas

SN - 1027-3956

ER -