El glutatión y las vitaminas C y E protegen en el daño renal agudo inducido por cromo en la rata

In Wistar female adult rats acute renal failure (ARF) was induced with a single dose of potassium chromate (20 mg/kg, subcutaneous). Four groups, control group and three chromium treated-groups, one of them was received vitamins C (200 mg/kg) and vitamin E (alfa-tocopherol, 100 mg/kg) and another glutathione (50 mg/kg) per os. In urine and blood samples obtained on days 1, 3, 5, 10 and 14, creatinine and sodium concentration were measured. In urine proteins and glucose were also measured. PAH uptake by cortical renal tissue was determined. In ARF, results revealed proximal renal function altered, increased creatinine serum and decreased glomerular filtration. In the antioxidants treated-groups proximal function were preserved and did not prevent totally glomerular and distal dysfunction. The recovery was faster in the presence of the antioxidants ones.