TY - JOUR
T1 - Global analysis of virus dynamics model with logistic mitosis, cure rate and delay in virus production
AU - Vargas-De-León, Cruz
AU - Chí, Noé Chan
AU - Vales, Eric Ávila
N1 - Publisher Copyright:
Copyright © 2014 John Wiley & Sons, Ltd.
PY - 2015/3/15
Y1 - 2015/3/15
N2 - In this paper, we study a virus dynamics model with logistic mitosis, cure rate, and intracellular delay. By means of construction of a suitable Lyapunov functionals, obtained by linear combinations of Volterra - type functions, composite quadratic functions and Volterra - type functionals, we provide the global stability for this model. If R0, the basic reproductive number, satisfies R0 & le; 1, then the infection-free equilibrium state is globally asymptotically stable. Our system is persistent if R0 > 1. On the other hand, if R0 > 1, then infection-free equilibrium becomes unstable and a unique infected equilibrium exists. The local stability analysis is carried out for the infected equilibrium, and it is shown that, if the parameters satisfy a condition, the infected equilibrium can be unstable and a Hopf bifurcation can occur. We also have that if R0 > 1, then the infected equilibrium state is globally asymptotically stable if a sufficient condition is satisfied. We illustrate our findings with some numerical simulations.
AB - In this paper, we study a virus dynamics model with logistic mitosis, cure rate, and intracellular delay. By means of construction of a suitable Lyapunov functionals, obtained by linear combinations of Volterra - type functions, composite quadratic functions and Volterra - type functionals, we provide the global stability for this model. If R0, the basic reproductive number, satisfies R0 & le; 1, then the infection-free equilibrium state is globally asymptotically stable. Our system is persistent if R0 > 1. On the other hand, if R0 > 1, then infection-free equilibrium becomes unstable and a unique infected equilibrium exists. The local stability analysis is carried out for the infected equilibrium, and it is shown that, if the parameters satisfy a condition, the infected equilibrium can be unstable and a Hopf bifurcation can occur. We also have that if R0 > 1, then the infected equilibrium state is globally asymptotically stable if a sufficient condition is satisfied. We illustrate our findings with some numerical simulations.
KW - Global stability
KW - Hopf bifurcation
KW - Local stability
KW - Lyapunov functionals
KW - Permanence
KW - Time delay
UR - http://www.scopus.com/inward/record.url?scp=84921889343&partnerID=8YFLogxK
U2 - 10.1002/mma.3096
DO - 10.1002/mma.3096
M3 - Artículo
SN - 0170-4214
VL - 38
SP - 646
EP - 664
JO - Mathematical Methods in the Applied Sciences
JF - Mathematical Methods in the Applied Sciences
IS - 4
ER -