Genotoxic evaluation of letimide with the mouse bone marrow micronucleus test

S. Díaz Barriga-Arceo, E. Madrigal-Bujaidar

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Letimide, 3[2-(diethylamino)ethyl]-2H-1,3-benzoxazine-2,4(3H)-dione, a new analgesic, is a cyclic derivative of a salicylamide with a higher pharmacological potency than acetylsalicylic acid. In this study we evaluated its clastogenic activity using the micronucleus test in vivo. Our results did not show any clastogenic effect produced by letimide as compared with control mice and animals treated with cyclophosphamide. © 1991.
Original languageAmerican English
Pages (from-to)95-98
Number of pages85
JournalToxicology Letters
DOIs
StatePublished - 1 Jan 1991

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acetylsalicylic acid
Micronucleus Tests
bone marrow
Dione
mice
animals
Bone
Animals
Bone Marrow
Derivatives
Acids
evaluation
Cyclophosphamide
Aspirin
Analgesics
Pharmacology
letimide

Cite this

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abstract = "Letimide, 3[2-(diethylamino)ethyl]-2H-1,3-benzoxazine-2,4(3H)-dione, a new analgesic, is a cyclic derivative of a salicylamide with a higher pharmacological potency than acetylsalicylic acid. In this study we evaluated its clastogenic activity using the micronucleus test in vivo. Our results did not show any clastogenic effect produced by letimide as compared with control mice and animals treated with cyclophosphamide. {\circledC} 1991.",
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Genotoxic evaluation of letimide with the mouse bone marrow micronucleus test. / Díaz Barriga-Arceo, S.; Madrigal-Bujaidar, E.

In: Toxicology Letters, 01.01.1991, p. 95-98.

Research output: Contribution to journalArticle

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