TY - JOUR
T1 - Genotoxic evaluation of letimide with the mouse bone marrow micronucleus test
AU - Díaz Barriga-Arceo, S.
AU - Madrigal-Bujaidar, E.
N1 - Funding Information:
E. Madrigal-Bujaidar is holder of a grant from COFAA. awarded a fellowship from CONACYT.
PY - 1991/4
Y1 - 1991/4
N2 - Letimide, 3[2-(diethylamino)ethyl]-2H-1,3-benzoxazine-2,4(3H)-dione, a new analgesic, is a cyclic derivative of a salicylamide with a higher pharmacological potency than acetylsalicylic acid. In this study we evaluated its clastogenic activity using the micronucleus test in vivo. Our results did not show any clastogenic effect produced by letimide as compared with control mice and animals treated with cyclophosphamide.
AB - Letimide, 3[2-(diethylamino)ethyl]-2H-1,3-benzoxazine-2,4(3H)-dione, a new analgesic, is a cyclic derivative of a salicylamide with a higher pharmacological potency than acetylsalicylic acid. In this study we evaluated its clastogenic activity using the micronucleus test in vivo. Our results did not show any clastogenic effect produced by letimide as compared with control mice and animals treated with cyclophosphamide.
KW - Analgesic
KW - Letimide
KW - Micronucleus test
KW - Mouse bone marrow
KW - Salicylamide derivative
UR - http://www.scopus.com/inward/record.url?scp=0026073746&partnerID=8YFLogxK
U2 - 10.1016/0378-4274(91)90094-M
DO - 10.1016/0378-4274(91)90094-M
M3 - Artículo
SN - 0378-4274
VL - 56
SP - 95
EP - 98
JO - Toxicology Letters
JF - Toxicology Letters
IS - 1-2
ER -