TY - JOUR
T1 - “Genetic regulation of Mycobacterium tuberculosis in a lipid-rich environment”
AU - Aguilar-Ayala, Diana A.
AU - Palomino, Juan Carlos
AU - Vandamme, Peter
AU - Martin, Anandi
AU - Gonzalez-y-Merchand, Jorge A.
N1 - Publisher Copyright:
© 2016 Elsevier B.V.
PY - 2017/11
Y1 - 2017/11
N2 - Tuberculosis (TB) remains as one of the leading causes of morbidity and mortality among infectious diseases worldwide. Although lipids (mainly fatty acids and cholesterol) have been reported to play an important role during active and latent infection of M. tuberculosis, there are other molecular aspects of bacterial response to those substrates that are not fully understood, involving gene regulation background. This review highlights recent insights on pathogen gene expression: regulation during its active growth, during survival in presence of lipids and under variable hostile host microenvironments. We also propose several application options of this knowledge that may contribute for improved TB control.
AB - Tuberculosis (TB) remains as one of the leading causes of morbidity and mortality among infectious diseases worldwide. Although lipids (mainly fatty acids and cholesterol) have been reported to play an important role during active and latent infection of M. tuberculosis, there are other molecular aspects of bacterial response to those substrates that are not fully understood, involving gene regulation background. This review highlights recent insights on pathogen gene expression: regulation during its active growth, during survival in presence of lipids and under variable hostile host microenvironments. We also propose several application options of this knowledge that may contribute for improved TB control.
KW - M. tuberculosis
KW - M. tuberculosis gene expression
KW - M. tuberculosis lipids
KW - M. tuberculosis microenvironments
KW - M. tuberculosis stress responses
UR - http://www.scopus.com/inward/record.url?scp=85006074487&partnerID=8YFLogxK
U2 - 10.1016/j.meegid.2016.10.015
DO - 10.1016/j.meegid.2016.10.015
M3 - Artículo de revisión
C2 - 27771519
SN - 1567-1348
VL - 55
SP - 392
EP - 402
JO - Infection, Genetics and Evolution
JF - Infection, Genetics and Evolution
ER -