“Genetic regulation of Mycobacterium tuberculosis in a lipid-rich environment”

Diana A. Aguilar-Ayala, Juan Carlos Palomino, Peter Vandamme, Anandi Martin, Jorge A. Gonzalez-y-Merchand

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Tuberculosis (TB) remains as one of the leading causes of morbidity and mortality among infectious diseases worldwide. Although lipids (mainly fatty acids and cholesterol) have been reported to play an important role during active and latent infection of M. tuberculosis, there are other molecular aspects of bacterial response to those substrates that are not fully understood, involving gene regulation background. This review highlights recent insights on pathogen gene expression: regulation during its active growth, during survival in presence of lipids and under variable hostile host microenvironments. We also propose several application options of this knowledge that may contribute for improved TB control.

Original languageEnglish
Pages (from-to)392-402
Number of pages11
JournalInfection, Genetics and Evolution
Volume55
DOIs
StatePublished - Nov 2017

Keywords

  • M. tuberculosis
  • M. tuberculosis gene expression
  • M. tuberculosis lipids
  • M. tuberculosis microenvironments
  • M. tuberculosis stress responses

Fingerprint

Dive into the research topics of '“Genetic regulation of Mycobacterium tuberculosis in a lipid-rich environment”'. Together they form a unique fingerprint.

Cite this