TY - JOUR
T1 - Genetic polymorphisms in the cag pathogenicity island of Helicobacter pylori and risk of stomach cancer and high-grade premalignant gastric lesions
AU - Canzian, Federico
AU - Rizzato, Cosmeri
AU - Obazee, Ofure
AU - Stein, Angelika
AU - Flores-Luna, Lourdes
AU - Camorlinga-Ponce, Margarita
AU - Mendez-Tenorio, Alfonso
AU - Vivas, Jorge
AU - Trujillo, Esperanza
AU - Jang, Hyejong
AU - Chen, Wei
AU - Kasamatsu, Elena
AU - Bravo, Maria Mercedes
AU - Torres, Javier
AU - Muñoz, Nubia
AU - Kato, Ikuko
N1 - Publisher Copyright:
© 2020 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC
PY - 2020/11/1
Y1 - 2020/11/1
N2 - Helicobacter pylori (Hp) infects the stomach of about half of the human population and is strongly associated with the risk of gastric cancer (GC) and its premalignant precursors. The cag pathogenicity island (cagPAI) is a region of the Hp genome encoding for key molecular machinery involved in the infection process. Following a sequencing study, we selected 50 genetic polymorphisms located in seven cagPAI genes and tested their associations with the risk of advanced gastric premalignant lesions and GC in 1220 subjects from various Latin American populations showing the whole spectrum of phenotypes from gastritis to GC. We found that three polymorphisms of cagA are associated with the risk of advanced gastric premalignant lesions (incomplete intestinal metaplasia [ie, Type 2 and 3] or dysplasia), and that six polymorphisms located in cagA, cagL and cagI were associated with risk of GC. When corrected for multiple testing none of the associations were statistically significant. However, scores built by integrating the individual polymorphisms were significantly associated with the risk of advanced gastric premalignant lesions and GC. These results have the potential of establishing markers for risk stratification in the general population, in view of targeting Hp eradication to high-risk population groups.
AB - Helicobacter pylori (Hp) infects the stomach of about half of the human population and is strongly associated with the risk of gastric cancer (GC) and its premalignant precursors. The cag pathogenicity island (cagPAI) is a region of the Hp genome encoding for key molecular machinery involved in the infection process. Following a sequencing study, we selected 50 genetic polymorphisms located in seven cagPAI genes and tested their associations with the risk of advanced gastric premalignant lesions and GC in 1220 subjects from various Latin American populations showing the whole spectrum of phenotypes from gastritis to GC. We found that three polymorphisms of cagA are associated with the risk of advanced gastric premalignant lesions (incomplete intestinal metaplasia [ie, Type 2 and 3] or dysplasia), and that six polymorphisms located in cagA, cagL and cagI were associated with risk of GC. When corrected for multiple testing none of the associations were statistically significant. However, scores built by integrating the individual polymorphisms were significantly associated with the risk of advanced gastric premalignant lesions and GC. These results have the potential of establishing markers for risk stratification in the general population, in view of targeting Hp eradication to high-risk population groups.
KW - Helicobacter pylori
KW - gastric cancer
KW - genetic polymorphisms
KW - pathogenicity island
KW - premalignant gastric lesions
UR - http://www.scopus.com/inward/record.url?scp=85084585826&partnerID=8YFLogxK
U2 - 10.1002/ijc.33032
DO - 10.1002/ijc.33032
M3 - Artículo
C2 - 32363734
SN - 0020-7136
VL - 147
SP - 2437
EP - 2445
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 9
ER -