TY - JOUR
T1 - Gastroprotective effect of calealactone B
T2 - Lack of involvement of prostaglandins, nitric oxide and sulfhydryls
AU - Sánchez-Mendoza, María Elena
AU - López-Lorenzo, Yaraset
AU - Matus-Meza, Audifás Salvador
AU - Arrieta, Jesús
N1 - Publisher Copyright:
© 2017 Wiley Periodicals, Inc.
PY - 2018/2
Y1 - 2018/2
N2 - (Table presented.). The gastroprotective effect of calealactone B, isolated from Calea urticifolia was assessed in an ethanol-induced model of gastric lesioning. The possible involvement of prostaglandins, nitric oxide (NO) and sulfhydryl groups in the mechanism of action of calealactone B was also assessed. Calealactone B inhibited ethanol-induced gastric injuries with a maximal effect (95.3 ± 2.6%) at 30 mg kg−1. A similar value was obtained at 10 mg kg−1 (83.5 ± 7.7%). Meanwhile, the reference anti-ulcer drug, carbenoxolone, an 11β-hydroxysteroid dehydrogenase (11β-HSD) inhibitor administered at 30 mg kg−1 showed 63.5 ± 9.4% gastroprotection. Hence, calealactone B was more potent than carbenoxolone. Pretreatment with indomethacin, L-NAME or NEM did not reverse the effects of calealactone B, indicating that prostaglandins, NO and sulfhydryl compounds do not participate in its mechanism of action.
AB - (Table presented.). The gastroprotective effect of calealactone B, isolated from Calea urticifolia was assessed in an ethanol-induced model of gastric lesioning. The possible involvement of prostaglandins, nitric oxide (NO) and sulfhydryl groups in the mechanism of action of calealactone B was also assessed. Calealactone B inhibited ethanol-induced gastric injuries with a maximal effect (95.3 ± 2.6%) at 30 mg kg−1. A similar value was obtained at 10 mg kg−1 (83.5 ± 7.7%). Meanwhile, the reference anti-ulcer drug, carbenoxolone, an 11β-hydroxysteroid dehydrogenase (11β-HSD) inhibitor administered at 30 mg kg−1 showed 63.5 ± 9.4% gastroprotection. Hence, calealactone B was more potent than carbenoxolone. Pretreatment with indomethacin, L-NAME or NEM did not reverse the effects of calealactone B, indicating that prostaglandins, NO and sulfhydryl compounds do not participate in its mechanism of action.
KW - Calea urticifolia
KW - calealactone B
KW - gastroprotection
UR - http://www.scopus.com/inward/record.url?scp=85042076034&partnerID=8YFLogxK
U2 - 10.1002/ddr.21415
DO - 10.1002/ddr.21415
M3 - Artículo
C2 - 29076166
SN - 0272-4391
VL - 79
SP - 11
EP - 15
JO - Drug Development Research
JF - Drug Development Research
IS - 1
ER -