Gastroprotective activity of methyleugenol from Peperomia Hispidula on ethanol-induced gastric lesions in rats

María Elena Sánchez-Mendoza, Leticia Cruz-Antonio, Daniel Arrieta-Baez, Ivonne María Olivares-Corichi, Raúl Rojas-Martínez, Dorismilda Martínez-Cabrera, Jesús Arrieta

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Abstract

© 2015 Asian Network for Scientific Information. Peperomia hispidula is used in traditional Mexican herbal medicine to treat gastric ulcers. However, this use has not been corroborated scientifically. Hence, the gastroprotective activity of P. hispidula was herein evaluated, as well as the role of endogenous NO, sulfhydryl groups and prostaglandins in the gastroprotective effect shown by one compound. The activity of P. hispidula was evaluated by using an animal model of gastric lesions induced by absolute ethanol in Wistar rats. Methyleugenol was isolated via silica gel column chromatography. The cytoprotective mechanisms of this compound were evaluated in relation to nitric oxide (pretreatment with L-NAME), sulfhydryl groups (pretreatment with NEM) and prostaglandins (pretreatment with indomethacin). The hexane and dichloromethane extracts showed gastroprotective activity, the latter (at 100 mg kg <sup > -1 </sup > ) having the greatest effect (91.55±3.12%). Methyleugenol was identified as one of the most active compounds in this extract. The gastroprotective activity of methyleugenol at 100 mg kg <sup > -1 </sup > was not attenuated by pretreatment with L-NAME, NEM or indomethacin. Methyleugenol was identified as one of the compounds of P. hispidula that exerts a gastroprotective effect. The results suggest that the gastroprotective mechanism of methyleugenol does not involve nitric oxide, sulfhydryl groups or prostaglandins.
Original languageAmerican English
Pages (from-to)697-704
Number of pages8
JournalInternational Journal of Pharmacology
DOIs
StatePublished - 1 Jan 2015

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methyleugenol
Peperomia
Stomach
Ethanol
Prostaglandins
NG-Nitroarginine Methyl Ester
Indomethacin
Nitric Oxide
Information Services
Herbal Medicine
Methylene Chloride
Silica Gel
Hexanes
Stomach Ulcer
Gel Chromatography
Wistar Rats
Animal Models

Cite this

@article{7ce32fe38b8b46039038334b91d47e64,
title = "Gastroprotective activity of methyleugenol from Peperomia Hispidula on ethanol-induced gastric lesions in rats",
abstract = "{\circledC} 2015 Asian Network for Scientific Information. Peperomia hispidula is used in traditional Mexican herbal medicine to treat gastric ulcers. However, this use has not been corroborated scientifically. Hence, the gastroprotective activity of P. hispidula was herein evaluated, as well as the role of endogenous NO, sulfhydryl groups and prostaglandins in the gastroprotective effect shown by one compound. The activity of P. hispidula was evaluated by using an animal model of gastric lesions induced by absolute ethanol in Wistar rats. Methyleugenol was isolated via silica gel column chromatography. The cytoprotective mechanisms of this compound were evaluated in relation to nitric oxide (pretreatment with L-NAME), sulfhydryl groups (pretreatment with NEM) and prostaglandins (pretreatment with indomethacin). The hexane and dichloromethane extracts showed gastroprotective activity, the latter (at 100 mg kg -1 ) having the greatest effect (91.55±3.12{\%}). Methyleugenol was identified as one of the most active compounds in this extract. The gastroprotective activity of methyleugenol at 100 mg kg -1 was not attenuated by pretreatment with L-NAME, NEM or indomethacin. Methyleugenol was identified as one of the compounds of P. hispidula that exerts a gastroprotective effect. The results suggest that the gastroprotective mechanism of methyleugenol does not involve nitric oxide, sulfhydryl groups or prostaglandins.",
author = "S{\'a}nchez-Mendoza, {Mar{\'i}a Elena} and Leticia Cruz-Antonio and Daniel Arrieta-Baez and Olivares-Corichi, {Ivonne Mar{\'i}a} and Ra{\'u}l Rojas-Mart{\'i}nez and Dorismilda Mart{\'i}nez-Cabrera and Jes{\'u}s Arrieta",
year = "2015",
month = "1",
day = "1",
doi = "10.3923/ijp.2015.697.704",
language = "American English",
pages = "697--704",
journal = "International Journal of Pharmacology",
issn = "1811-7775",
publisher = "Asian Network for Scientific Information",

}

Gastroprotective activity of methyleugenol from Peperomia Hispidula on ethanol-induced gastric lesions in rats. / Sánchez-Mendoza, María Elena; Cruz-Antonio, Leticia; Arrieta-Baez, Daniel; Olivares-Corichi, Ivonne María; Rojas-Martínez, Raúl; Martínez-Cabrera, Dorismilda; Arrieta, Jesús.

In: International Journal of Pharmacology, 01.01.2015, p. 697-704.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Gastroprotective activity of methyleugenol from Peperomia Hispidula on ethanol-induced gastric lesions in rats

AU - Sánchez-Mendoza, María Elena

AU - Cruz-Antonio, Leticia

AU - Arrieta-Baez, Daniel

AU - Olivares-Corichi, Ivonne María

AU - Rojas-Martínez, Raúl

AU - Martínez-Cabrera, Dorismilda

AU - Arrieta, Jesús

PY - 2015/1/1

Y1 - 2015/1/1

N2 - © 2015 Asian Network for Scientific Information. Peperomia hispidula is used in traditional Mexican herbal medicine to treat gastric ulcers. However, this use has not been corroborated scientifically. Hence, the gastroprotective activity of P. hispidula was herein evaluated, as well as the role of endogenous NO, sulfhydryl groups and prostaglandins in the gastroprotective effect shown by one compound. The activity of P. hispidula was evaluated by using an animal model of gastric lesions induced by absolute ethanol in Wistar rats. Methyleugenol was isolated via silica gel column chromatography. The cytoprotective mechanisms of this compound were evaluated in relation to nitric oxide (pretreatment with L-NAME), sulfhydryl groups (pretreatment with NEM) and prostaglandins (pretreatment with indomethacin). The hexane and dichloromethane extracts showed gastroprotective activity, the latter (at 100 mg kg -1 ) having the greatest effect (91.55±3.12%). Methyleugenol was identified as one of the most active compounds in this extract. The gastroprotective activity of methyleugenol at 100 mg kg -1 was not attenuated by pretreatment with L-NAME, NEM or indomethacin. Methyleugenol was identified as one of the compounds of P. hispidula that exerts a gastroprotective effect. The results suggest that the gastroprotective mechanism of methyleugenol does not involve nitric oxide, sulfhydryl groups or prostaglandins.

AB - © 2015 Asian Network for Scientific Information. Peperomia hispidula is used in traditional Mexican herbal medicine to treat gastric ulcers. However, this use has not been corroborated scientifically. Hence, the gastroprotective activity of P. hispidula was herein evaluated, as well as the role of endogenous NO, sulfhydryl groups and prostaglandins in the gastroprotective effect shown by one compound. The activity of P. hispidula was evaluated by using an animal model of gastric lesions induced by absolute ethanol in Wistar rats. Methyleugenol was isolated via silica gel column chromatography. The cytoprotective mechanisms of this compound were evaluated in relation to nitric oxide (pretreatment with L-NAME), sulfhydryl groups (pretreatment with NEM) and prostaglandins (pretreatment with indomethacin). The hexane and dichloromethane extracts showed gastroprotective activity, the latter (at 100 mg kg -1 ) having the greatest effect (91.55±3.12%). Methyleugenol was identified as one of the most active compounds in this extract. The gastroprotective activity of methyleugenol at 100 mg kg -1 was not attenuated by pretreatment with L-NAME, NEM or indomethacin. Methyleugenol was identified as one of the compounds of P. hispidula that exerts a gastroprotective effect. The results suggest that the gastroprotective mechanism of methyleugenol does not involve nitric oxide, sulfhydryl groups or prostaglandins.

U2 - 10.3923/ijp.2015.697.704

DO - 10.3923/ijp.2015.697.704

M3 - Article

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EP - 704

JO - International Journal of Pharmacology

JF - International Journal of Pharmacology

SN - 1811-7775

ER -